Results 281 to 290 of about 177,877 (294)

Regulation of epidermin biosynthetic genes by EpiQ

Molecular Microbiology, 1993
SummaryWe investigated the role of epiQ in the biosynthesis of the lantibiotic epidermin. epiQ was essential for epidermin production. It was shown that EpiQ controls epidermin production by transcriptionally activating the epiA promoter, used for transcription of most of the epidermin biosynthetic genes.
A, Peschel, J, Augustin, T, Kupke, S, Stevanovic, F, Götz   +4 more
openaire   +2 more sources

Lessons from the rifamycin biosynthetic gene cluster

Current Opinion in Chemical Biology, 1999
There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the enzyme assembling the polyketide backbone of ...
H G, Floss, T W, Yu
openaire   +2 more sources

Transcriptional regulation of yeast phospholipid biosynthetic genes

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007
The last several years have been witness to significant developments in understanding transcriptional regulation of the yeast phospholipid structural genes. The response of most phospholipid structural genes to inositol is now understood on a mechanistic level. The roles of specific activators and repressors are also well established.
Meng, Chen, Leandria C, Hancock, John M, Lopes   +2 more
openaire   +2 more sources

Characterization of the Actinonin Biosynthetic Gene Cluster

ChemBioChem, 2018
AbstractThe hydroxamate moiety of the natural product actinonin mediates inhibition of metalloproteinases because of its chelating properties towards divalent cations in the active site of those enzymes. Owing to its antimicrobial activity, actinonin has served as a lead compound for the development of new antibiotic drug candidates.
Felix Wolf, Franziska Leipoldt, Andreas Kulik, Daniel Wibberg, Jörn Kalinowski, Leonard Kaysser   +5 more
openaire   +2 more sources

The tylosin-biosynthetic genes of Streptomyces fradiae

Antonie van Leeuwenhoek, 2001
The tylosin-biosynthetic (tyl) gene cluster occupies about 1% of the genome of Streptomycesfradiae and includes at least 43 open reading frames. In addition to structural genes required for tylosin production, the tyl cluster contains three resistance determinants and several regulatory genes.
E, Cundliffe, N, Bate, A, Butler, S, Fish, A, Gandecha, L, Merson-Davies   +5 more
openaire   +2 more sources

Maize Methods—Starch Biosynthetic Genes

1994
Starch biosynthetic genes are of interest to maize biologists for a number of reasons. These genes have been used to follow chromosomal behavior during endosperm development, as traps for transposable elements and other mutations, and as marker genes to follow tissue-specific patterns of expression.
L. Curtis Hannah, Edwin R. Duke, Karen E. Koch, B. Gregory Cobb   +3 more
openaire   +1 more source

ChemInform Abstract: Ergot Alkaloids: Structure Diversity, Biosynthetic Gene Clusters and Functional Proof of Biosynthetic Genes.

ChemInform, 2011
AbstractReview: 148 refs.
Christiane Wallwey, Shu‐Ming Li
openaire   +1 more source

A gene cluster of the ochratoxin A biosynthetic genes inPenicillium

Mycotoxin Research, 2006
A putative ochratoxin A (OTA) biosynthetic gene cluster inP. nordicum has been identified. The first part of the gene cluster is located on a DNA fragment of 10 kb in length and harbours three genes. A gene with high homology to an alkaline serine protease gene (accession number AY557343), which represents the upstream border of the cluster ...
R, Geisen, M, Schmidt-Heydt, A, Karolewiez   +2 more
openaire   +2 more sources

Lichen Biosynthetic Gene Clusters. Part I. Genome Sequencing Reveals a Rich Biosynthetic Potential

Journal of Natural Products, 2018
Lichens are symbionts of fungi and algae that produce diverse secondary metabolites with useful properties. Little is known of lichen natural product biosynthesis because of the challenges of working with lichenizing fungi. We describe the first attempt to comprehensively profile the genetic secondary metabolome of a lichenizing fungus.
Robert L. Bertrand, Mona Abdel-Hameed, John L. Sorensen   +2 more
openaire   +2 more sources

Riboflavin biosynthetic genes of Corynebacterium ammoniagenes

Journal of Fermentation and Bioengineering, 1998
Riboflavin-requiring mutants were isolated from Corynebacterium ammoniagenes. One of the mutants, RK122, accumulated 6,7-dimethyl-8-ribityllumazine (DMRL), a direct precursor of riboflavin, in the culture medium. Chromosomal DNA fragments that complement the riboflavin requirement of RK122 were cloned and sequenced.
Satoshi Koizumi, Sadao Teshiba
openaire   +1 more source