Results 61 to 70 of about 102,201 (258)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Enzymatic Hydrolysis of Cellulosic Materials: A Kinetic Studycarniti

, 1984
Biotechnology and Bioengineering, 26, 1233 (1984)
P. L. Beltrame, A. Marzetti, P. Carniti, V. Sarto, B. Focher   +4 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Protocol for the development of mRNA lipid nanoparticle vaccines and analysis of immunization efficiency in mice

STAR Protocols
Summary: Here, we present a protocol for the development of mRNA-loaded lipid nanoparticle (LNP) vaccines for target antigen sequences of interest. We describe key steps required to design and synthesize mRNA constructs, their LNP encapsulation, and ...
Neha Karekar, Ashley Reid Cahn, Judit Morla-Folch, Alexis Saffon, Ross W. Ward, Aparna Ananthanarayanan, Abraham J.P. Teunissen, Nina Bhardwaj, Nicolas Vabret   +8 more
doaj   +1 more source

Current Developments in Biotechnology and Bioengineering: Membrane Technology for Sustainable Water and Energy Management

, 2023
Current Developments in Biotechnology and Bioengineering: Membrane Technology for Sustainable Water and Energy Management covers a variety of advanced technologies for membrane processes, including water/wastewater treatment and reuse, membrane materials,
Bui, XT, Guo, W, Chiemchaisri, C, Pandey, A   +3 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Protocols for translocation processes of flexible polymers through a pore using LAMMPS

STAR Protocols
Summary: Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) is an open-source, powerful simulator with a customizable platform for extensive Langevin dynamics simulations.
Vrinda Garg, Rejoy Mathew, Arindam Chatterjee, Surya K. Ghosh   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Protocol for quantification of fungal biomass in fungal composite materials based on ergosterol extraction

STAR Protocols
Summary: Fungal composite materials are lignocellulosic particles and possible inorganic additives, connected by fungal hyphae. Here, we provide a protocol for extracting the cell membrane constituent ergosterol from dried fungal composite material to ...
Carsten Freidank-Pohl, Antonia Geyer, Ulla Simon   +2 more
doaj   +1 more source

Editorial: Extracellular Vesicle Treatment, Epigenetic Modification and Cell Reprogramming to Promote Bone and Cartilage Regeneration

, 2021
10.3389/fbioe.2021.678014FRONTIERS IN BIOENGINEERING AND ...
He, Tong-Chuan, Toh, Wei Seong, Dong, Yufeng, Pei, Ming, Li, Wan-Ju, Pei, Yixuan Amy, Ming Pei, Yufeng Dong, Yixuan Amy Pei, Wan-Ju Li, Tong-Chuan He, Wei Seong Toh   +11 more
core   +1 more source