Results 191 to 200 of about 338,983 (344)

Protein chirality as a determinant of ligand affinity: insights from l- and d-streptavidin. [PDF]

Chem Sci
Giesler RJ, Woodham PCS, Draper SRE, Spaltenstein P, Whitby FG, Hill CP, Kay MS.   +6 more
europepmc   +1 more source

Efficacy of Compound GV-350 with Tricofer® Iron, Cystine and Biotin in the Management of Telogen Effluvium in Women with Iron Deficiency

openalex   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Pretargeted Anti-CD20 Radioimmunotherapy with scFv Fusion Protein Safely Combines with BEAM and ASCT in Patients with High-risk B-cell Lymphomas. [PDF]

Mol Cancer Ther
Orozco JJ, Matesan MC, Lundberg SJ, Haaf RL, Miyaoka RS, Fisher DR, Gooley TA, Green DJ, Sandmaier BM, Martin PS, Gopal AK.   +10 more
europepmc   +1 more source

Structural and Functional Studies of the Biotin Protein Ligase from Aquifex aeolicus Reveal a Critical Role for a Conserved Residue in Target Specificity

, 2009
Cécile Tron, I.W. McNae, Margaret Nutley, David J. Clarke, Alan Cooper, Malcolm D. Walkinshaw, Robert L. Baxter, Dominic J. Campopiano   +7 more
openalex   +2 more sources

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

Advanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta, Mette Galsgaard Malle, Emily Tsang, Marjan Omer, Mads K. Skaanning, Sarah Youssef, Jørgen Kjems, Kurt V. Gothelf   +7 more
wiley   +1 more source

Demonstration of the photo-controllability of the bistable opsin OPN5 using upconversion nanoparticles with multiple emission peaks upon near-infrared photoexcitation. [PDF]

Nanoscale Adv
Kotegawa F, Takahashi M, Higashimine K, Hiratsuka Y, Matsumura K, Kojima D, Maenosono S.   +6 more
europepmc   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Single-molecule experiments reveal NusG displaces transcription initiation factor σ70 from mature elongation complexes. [PDF]

Nucleic Acids Res
Mukherjee P, Alim S, Shahu S, Mondal S, Chattopadhyay K, Ganji M, Mazumder A.   +6 more
europepmc   +1 more source

Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus

, 2007
Michael Gralla, Gabriela Camporeale, Janos Zempleni   +2 more
openalex   +1 more source