Results 151 to 160 of about 164,185 (363)
Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li +7 more
wiley +1 more source
Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short
CHIMIA, 2011 Thanks to the stability, good availability, stereoselectivity and broad substrate specificity, oligosaccharide synthesis catalyzed by glycosidases represents an elegant way to complex carbohydrate structures.
Pavla Bojarová, Vladimír Kren
doaj +1 more source
Comparative Study of Extracellular Proteolytic, Cellulolytic, and Hemicellulolytic Enzyme Activities and Biotransformation of Palm Kernel Cake Biomass by Lactic Acid Bacteria Isolated from Malaysian Foods [PDF]
, 2019 Fu Haw Lee +6 more
openalex +1 more source
Drug Metabolism And Disposition, 2019 For therapeutic proteins, the currently established standard development path generally does not foresee biotransformation studies by default because it is well known that the clearance of therapeutic proteins proceeds via degradation to small peptides ...
S. Schadt +10 more
semanticscholar +1 more source
Epilepsia Open, EarlyView.Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza +4 more
wiley +1 more source
Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines
Environmental Toxicology and Chemistry, EarlyView.Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz +4 more
wiley +1 more source
Redox mediator, microaeration, and nitrate addition as engineering approaches to enhance the biotransformation of antibiotics in anaerobic reactors [PDF]
, 2020 José Gilmar da Silva do Nascimento +4 more
openalex +1 more source
Environmental Toxicology and Chemistry, EarlyView.Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers +10 more
wiley +1 more source
Food Bioengineering, EarlyView.Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi +4 more
wiley +1 more source