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Planta Medica, 2012
Using a standard two-stage fermentation technique, the fungus Beauveria bassiana (ATCC 7159) was found to convert the eudesmanolide vulgarin (1) to 1α,4α-dihydroxy-5αH,6,11βH-eudesman-6,12-olide (2). The use of the yeastHansenula anomala ATCC 20170 instead, produced the less polar 4α-hydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide(3), in addition to the ...
Khaled Y, Orabi +3 more
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Using a standard two-stage fermentation technique, the fungus Beauveria bassiana (ATCC 7159) was found to convert the eudesmanolide vulgarin (1) to 1α,4α-dihydroxy-5αH,6,11βH-eudesman-6,12-olide (2). The use of the yeastHansenula anomala ATCC 20170 instead, produced the less polar 4α-hydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide(3), in addition to the ...
Khaled Y, Orabi +3 more
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Biotransformations of Explosives
Biotechnology and Genetic Engineering Reviews, 2001(2001). Biotransformations of Explosives. Biotechnology and Genetic Engineering Reviews: Vol. 18, No. 1, pp. 171-217.
C E, French, S J, Rosser, N C, Bruce
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Clinical Pharmacology and Therapeutics, 1982
Two healthy subjects took 3H-digoxigenin-12 alpha and unlabeled digoxigenin. Metabolites were assayed by high-pressure liquid chromatography (HPLC) in serum and urine. Of the tritium activity in the serum at 30 min, less than 26% chromatographed with digoxigenin; the rest chromatographed as metabolites, most of which were polar.
H, Gault +3 more
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Two healthy subjects took 3H-digoxigenin-12 alpha and unlabeled digoxigenin. Metabolites were assayed by high-pressure liquid chromatography (HPLC) in serum and urine. Of the tritium activity in the serum at 30 min, less than 26% chromatographed with digoxigenin; the rest chromatographed as metabolites, most of which were polar.
H, Gault +3 more
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Biotransformations with nitrilases
Current Opinion in Chemical Biology, 2010The range of possible nitrilase applications has been recently broadened but in most cases the parameters of the reactions need to be improved to establish viable industrial processes. To achieve this goal, several methods have been used, primarily in screening for enzymes from new sources, enzyme improvement, substrate structure modification, medium ...
Ludmila, Martínková, Vladimír, Kren
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Biotechnology Advances, 2006
The main application of terpenes as fragrances and flavors depends on the absolute configuration of the compounds because enantiomers present different organoleptic properties. Biotransformations allow the production of regio- and stereoselective compounds under mild conditions. These products may be labeled as "natural".
Carla C C R, de Carvalho +1 more
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The main application of terpenes as fragrances and flavors depends on the absolute configuration of the compounds because enantiomers present different organoleptic properties. Biotransformations allow the production of regio- and stereoselective compounds under mild conditions. These products may be labeled as "natural".
Carla C C R, de Carvalho +1 more
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Biotransformation of Neuropeptides
Neuroendocrinology, 2008The ability of neuropeptides to act as precursors for smaller, biologically active fragments is discussed in terms of their biotransformation. This process may involve cleavage of the parent peptide by peptidase enzymes to produce shorter polypeptides with defined biological activity, though other enzymic processes such as sulphation and acetylation ...
E C, Griffths, J R, McDermott
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Clinical Pharmacology and Therapeutics, 1984
Serum digoxin and metabolites were assayed in plasma and urine by HPLC in 10 dialysis-dependent patients with end-stage renal failure (group I) and in five patients with comparatively normal renal function (group II) after ingestion of 150 muCi 3H-digoxin-12 alpha.
M H, Gault +6 more
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Serum digoxin and metabolites were assayed in plasma and urine by HPLC in 10 dialysis-dependent patients with end-stage renal failure (group I) and in five patients with comparatively normal renal function (group II) after ingestion of 150 muCi 3H-digoxin-12 alpha.
M H, Gault +6 more
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1978
During the past several years it has become generally accepted that the incidence of adverse reactions to drugs in patients increase with age (1–3). However, the reasons for the increased incidence are frequently obscure and often differ with the drug.
J R, Gillette, J A, Hinson
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During the past several years it has become generally accepted that the incidence of adverse reactions to drugs in patients increase with age (1–3). However, the reasons for the increased incidence are frequently obscure and often differ with the drug.
J R, Gillette, J A, Hinson
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Biotransformation of Phencyclidine
Drug Metabolism Reviews, 1985PCP is metabolized extensively in the body via a variety of metabolic routes. Biotransformation is a major mechanism of PCP elimination in humans and termination of PCP action in mice. In general, PCP metabolites are less active pharmacologically than PCP itself.
E J, Holsztynska, E F, Domino
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