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Biotransformations with nitrilases
Current Opinion in Chemical Biology, 2010The range of possible nitrilase applications has been recently broadened but in most cases the parameters of the reactions need to be improved to establish viable industrial processes. To achieve this goal, several methods have been used, primarily in screening for enzymes from new sources, enzyme improvement, substrate structure modification, medium ...
Ludmila, Martínková, Vladimír, Kren
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Biotransformation of Neuropeptides
Neuroendocrinology, 2008The ability of neuropeptides to act as precursors for smaller, biologically active fragments is discussed in terms of their biotransformation. This process may involve cleavage of the parent peptide by peptidase enzymes to produce shorter polypeptides with defined biological activity, though other enzymic processes such as sulphation and acetylation ...
E C, Griffths, J R, McDermott
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Clinical Pharmacology and Therapeutics, 1984
Serum digoxin and metabolites were assayed in plasma and urine by HPLC in 10 dialysis-dependent patients with end-stage renal failure (group I) and in five patients with comparatively normal renal function (group II) after ingestion of 150 muCi 3H-digoxin-12 alpha.
M H, Gault +6 more
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Serum digoxin and metabolites were assayed in plasma and urine by HPLC in 10 dialysis-dependent patients with end-stage renal failure (group I) and in five patients with comparatively normal renal function (group II) after ingestion of 150 muCi 3H-digoxin-12 alpha.
M H, Gault +6 more
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Biotransformations of Explosives
Biotechnology and Genetic Engineering Reviews, 2001(2001). Biotransformations of Explosives. Biotechnology and Genetic Engineering Reviews: Vol. 18, No. 1, pp. 171-217.
C E, French, S J, Rosser, N C, Bruce
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Biotransformations of Steroids
Critical Reviews in Biotechnology, 1988Different types of microbiological transformation of steroids are reviewed, with special attention given to bioconversions applied in the manufacturing of steroid hormones, i.e., 11 alpha- 11 beta-, 16 alpha-, 17 alpha-hydroxylations and 1-dehydrogenation.
Leon Sedlaczek, Leland L. Smith
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Toxicologic Pathology, 1988
About 4 million compounds have been described by chemists, and some 60,000 are presently on the market. The search for new chemicals with better properties and less toxicity continues, and future life quality will depend on our ability to find the safest compounds in each field of application.
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About 4 million compounds have been described by chemists, and some 60,000 are presently on the market. The search for new chemicals with better properties and less toxicity continues, and future life quality will depend on our ability to find the safest compounds in each field of application.
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1978
During the past several years it has become generally accepted that the incidence of adverse reactions to drugs in patients increase with age (1–3). However, the reasons for the increased incidence are frequently obscure and often differ with the drug.
J R, Gillette, J A, Hinson
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During the past several years it has become generally accepted that the incidence of adverse reactions to drugs in patients increase with age (1–3). However, the reasons for the increased incidence are frequently obscure and often differ with the drug.
J R, Gillette, J A, Hinson
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The biotransformation of nitroglycerin
Biochemical Pharmacology, 1965Abstract The transformation of nitroglycerin (NG) was accomplished by the formation of 1,2- and 1,3-dinitroglycerin. The dinitrates were resistant to further degradation and appeared as the urinary metabolites after the administration of NG. The dinitroglycerins were less active coronary vasodilators and blood pressure depressants than NG.
P, Needleman, J C, Krantz
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Biotransformation of Sevoflurane
Anesthesia & Analgesia, 1995Several characteristics of sevoflurane biotransformation are apparent from the preceding investigations. Metabolism is rapid, with fluoride and HFIP appearing in plasma within minutes after the start of sevoflurane administration (38-40,51). Peak plasma fluoride concentrations generally occur within approximately 1 h after the termination of ...
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Biotransformation of Phencyclidine
Drug Metabolism Reviews, 1985PCP is metabolized extensively in the body via a variety of metabolic routes. Biotransformation is a major mechanism of PCP elimination in humans and termination of PCP action in mice. In general, PCP metabolites are less active pharmacologically than PCP itself.
E J, Holsztynska, E F, Domino
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