Results 221 to 230 of about 62,756 (305)

Structure–Activity Relationship Study on Ligands Activating the Voltage‐Gated Potassium Channel KV7.1

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Activation of the voltage gated K+ channel KV7.1 leads to hyperpolarization shift of cell membranes. In a thorough SAR study eight positions of the lead compound (R)‐L3 were modified. (R)‐configuration, the indolylmethyl moiety in 3‐position and the 2‐fluorophenyl moiety in 5‐position appeared to be essential for high KV7.1 activation, whereas an OH ...
Florian Roßner, Judith Schmidt, Guiscard Seebohm, Bernhard Wünsch   +3 more
wiley   +1 more source

Recent Advances in Beta-Alanine Production via Enzymatic Catalysis and Microbial Whole-Cell Catalysis. [PDF]

Biology (Basel)
Yu J, Ma P, Zhang J, Zhang H, Tie H, Ruan H.   +5 more
europepmc   +1 more source

Transfer Learning Approaches in Bioprocess Engineering: Opportunities and Challenges

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1417-1431, June 2026.
ABSTRACT Transfer learning (TL) has recently emerged as a promising approach to overcoming one of the key limitations of bioprocess engineering: data scarcity. By leveraging knowledge from one bioprocess to another, TL allows existing models and data sets to be reused efficiently, accelerating process development, improving prediction accuracy, and ...
Daniel Barón Díaz, Anna‐Lena Drommershausen, Alexander Grünberger, Dirk Holtmann   +3 more
wiley   +1 more source

Whole-Cell Biocatalysis for the Production of Structurally Diverse Methoxydihydrochalcones: Broad Activity of the <i>Yarrowia</i> Clade. [PDF]

Molecules
Chlipała P, Mazur M, Kancelista A, Lazar Z, Janeczko T.   +4 more
europepmc   +1 more source

Subterranean environments contribute to three‐quarters of classified ecosystem services

Biological Reviews, Volume 101, Issue 3, Page 1582-1605, June 2026.
ABSTRACT Beneath the Earth's surface lies a network of interconnected caves, voids, and systems of fissures forming in rocks of sedimentary, igneous, or metamorphic origin. Although largely inaccessible to humans, this hidden realm supports and regulates services critical to ecological health and human well‐being.
Stefano Mammola, David Brankovits, Tiziana Di Lorenzo, Isabel R. Amorim, Raluca Ioana Bancila, Adrià Bellvert, Enrico Bernard, Anna Blomberg, Paulo A.V. Borges, Martina Cappelletti, Rodrigo Lopes Ferreira, Rosalina Gabriel, Diana M. P. Galassi, Laura Garzoli, Vasilis Gerovasileiou, Grant C. Hose, Kathryn L. Korbel, Simone Martino, Ana Z Miller, Nataša Mori, Veronica Nanni, Giuseppe Nicolosi, Mattia Saccò, Troy S. Sakihara, Marconi Souza Silva, Anne E. Tamalavage, Maja Zagmajster, Efraín Chávez, Christian Griebler, Pedro Cardoso, Alejandro Martínez   +30 more
wiley   +1 more source

Transcriptional Activity of Genes Related to the Biotransformation Process in the Development of Colorectal Cancer. [PDF]

Int J Mol Sci
Janikowska G, Janikowski T, Kuźbińska A, Opiłka M, Mazurek U, Lorenc Z.   +5 more
europepmc   +1 more source

The Development and Characterization of a Panel of Amine Dehydrogenases (AmDHs) and Amino Acid Dehydrogenases (AADHs)

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
The CoE‐AmDH panel enables sustainable access to chiral amines using diverse amine (AmDH) and amino acid dehydrogenases (AADH). Utilizing formate (FDH) or glucose dehydrogenase (GDH) for cofactor regeneration, this study establishes a robust screening platform for mild reductive aminations.
R. Tilly Bradshaw Allen, William R. Birmingham, Nicholas John Turner   +2 more
wiley   +1 more source

The involvement of miRNAs in CYP450 enzymes and UDP-glucuronosyltransferases regulation in the human liver. [PDF]

Sci Rep
Szeląg-Pieniek S, Perużyńska M, Komaniecka N, Kurzawski M, Oswald S, Łapczuk-Romańska J, Droździk M.   +6 more
europepmc   +1 more source

Stereoselective Production of Fluorohydrins Biocatalyzed by an Alcohol Dehydrogenase From Pichia glucozyma

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
Ketoreductase from Pichia glucozyma (KRED1‐Pglu) has been successfully employed for the stereoselective bioreduction of α‐halogenated ketones using the purified protein, or alternatively a lyophilized whole cell preparation overexpressed in E. coli. Better chemoselectivities were found with pure biocatalyst, obtaining a series of chiral fluorohydrins ...
Marina García‐Ramos, Iván Lavandera, Francesco Molinari, Martina Letizia Contente, Vicente Gotor‐Fernández   +4 more
wiley   +1 more source