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Bipolar disorder

open access: yesThe Lancet
The hallmark of bipolar disorder is hypomania or mania, and the predominant phase of illness is depression. Affecting approximately 40 million individuals worldwide, bipolar disorder is associated with a substantial psychosocial, medical, and financial burden and increased mortality from suicide and other causes.
Balwinder Singh   +9 more
openaire   +4 more sources

Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth

open access: yesTranslational Psychiatry, 2023
There is a gap in knowledge regarding the polygenic underpinnings of brain anomalies observed in youth bipolar disorder (BD). This study examined the association of a polygenic risk score for BD (BD-PRS) with grey matter structure and white matter ...
Xinyue Jiang   +8 more
doaj   +1 more source

A Feasibility Study of the Addition of STEPPS in Outpatients With Bipolar Disorder and Comorbid Borderline Personality Features: Promises and Pitfalls

open access: yesFrontiers in Psychiatry, 2021
Background: Pharmacotherapy is a cornerstone in bipolar disorder (BD) treatment whereas borderline personality disorder (BPD) is treated primarily with psychotherapy.
Georg Riemann   +7 more
doaj   +1 more source

Cognitive impairments and predominant polarity in bipolar disorder: a cross-sectional study

open access: yesInternational Journal of Bipolar Disorders, 2017
Background Bipolar disorder (BD) patients exhibit cognitive impairments during euthymic states. Studies suggest that manic episodes may be correlated to cognitive impairments.
Gabriel Okawa Belizario   +3 more
doaj   +1 more source

The functional impairment of different subtypes and occupational states in euthymic patients with bipolar disorder

open access: yesBMC Psychiatry, 2021
Background The aim was to explore the associations between clinical symptoms, demographic variables, social and neurocognitive functioning in euthymic patients with bipolar disorder (BD) stratified by subgroups of DSM-IV BD (type I (BD-I) and type II (BD-
Xinyu Liu   +6 more
doaj   +1 more source

Lifetime number of affective episodes and functioning in a cohort of patients with bipolar disorder: A cross-sectional study

open access: yesEuropean Psychiatry, 2023
Introduction Cognitive impairment has been commonly found in patients with bipolar disorder (BD).(1) Recent evidence supports the view that global and cognitive functioning decrease as a function of number of prior mood episodes, but the relationship is
L. Colomer   +6 more
doaj   +1 more source

Patient and physician perspectives of a smartphone application for depression: a qualitative study

open access: yesBMC Psychiatry, 2021
Background Despite an increasing number of smartphone apps, such therapeutic tools have not yet consistently demonstrated their efficacy and many suffer from low retention rates. To ensure the development of efficient apps associated with high adherence,
Marie-Camille Patoz   +9 more
doaj   +1 more source

Psychotropic drug repurposing for COVID-19: a systematic review

open access: yesEuropean Psychiatry, 2022
Introduction Recently, several antidepressants, mood stabilizers, and antipsychotics have been suggested to have favorable effects in the treatment of COVID-19.
U. Isayeva   +6 more
doaj   +1 more source

Pilot study of circulating cell-free mitochondrial DNA in relation to brain structure in youth bipolar disorder

open access: yesInternational Journal of Bipolar Disorders
Background Mitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Higher circulating cell-free mitochondrial DNA (ccf-mtDNA), generally reflecting poorer mitochondrial health, has been associated with greater symptoms ...
Suyi Shao   +8 more
doaj   +1 more source

The association of genetic variation in CACNA1C with resting-state functional connectivity in youth bipolar disorder

open access: yesInternational Journal of Bipolar Disorders, 2023
Background CACNA1C rs1006737 A allele, identified as a genetic risk variant for bipolar disorder (BD), is associated with anomalous functional connectivity in adults with and without BD.
Xinyue Jiang   +6 more
doaj   +1 more source

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