Results 41 to 50 of about 437,997 (293)

The association of genetic variation in CACNA1C with resting-state functional connectivity in youth bipolar disorder

International Journal of Bipolar Disorders, 2023
Background CACNA1C rs1006737 A allele, identified as a genetic risk variant for bipolar disorder (BD), is associated with anomalous functional connectivity in adults with and without BD.
Xinyue Jiang, Alysha A. Sultan, Mikaela K. Dimick, Clement C. Zai, James L. Kennedy, Bradley J. MacIntosh, Benjamin I. Goldstein   +6 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Elevated Familial Cardiovascular Burden Among Adolescents With Familial Bipolar Disorder

Frontiers in Psychiatry, 2019
Background: Bipolar disorder (BD) is one of the most heritable medical conditions, and certain phenotypic characteristics are especially familial in BD. BD is also strongly associated with elevated and premature cardiovascular disease (CVD) morbidity and
Simina Toma, Simina Toma, Lisa Fiksenbaum, Danielle Omrin, Benjamin I. Goldstein, Benjamin I. Goldstein, Benjamin I. Goldstein   +6 more
doaj   +1 more source

Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis – results to be interpreted with caution [PDF]

, 2010
Randomized, controlled trials have demonstrated efficacy for second-generation antipsychotics in the treatment of acute mania in bipolar disorder. Despite depression being considered the hallmark of bipolar disorder, there are no published systematic ...
Goikolea, José Manuel, Krishnadas, R., Vieta i Pascual, Eduard, 1963-, Valentí Ribas, Marc, Sánchez-Moreno, José, Torres, Ferran, Livingston, M., Cruz, Nuria   +7 more
core   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

The role of predominant polarity in older age bipolar disorder

International Journal of Bipolar Disorders
Introduction Predominant polarity (PP) has emerged as a valuable course specifier in bipolar disorder (BD) with implications for prognosis and treatment planning.
Constanza Sommerhoff, Marta Bort, Giulia D’Alessandro, Giovanna Fico, Michele De Prisco, Vincenzo Oliva, Brisa Solé, Carla Torrent, Andrea Murru, Andrea Ruiz, Arturo Rodríguez-Rey, Jose Sanchez-Moreno, Esther Jiménez, Anabel Martínez-Arán, Eduard Vieta, Laura Montejo   +15 more
doaj   +1 more source

Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders

Frontiers in Psychiatry
BackgroundPsychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear.
Umit Haluk Yesilkaya, Umit Haluk Yesilkaya, Xi Chen, Xi Chen, Lauren Watford, Emma McCoy, Meltem Sen, Ilgin Genc, Fei Du, Fei Du, Dost Ongur, Dost Ongur, Cagri Yuksel, Cagri Yuksel   +13 more
doaj   +1 more source

Pediyatrik tonsillektomide dört farklı tekniğin karşılaştırılması

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2022
Amaç: Bu çalışmamızda tonsillektomi yöntemlerinin operasyon süreleri intraoperatif kanama postoperatif tam iyileşme süresi, postoperatif ağrı açısından karşılaştırırken uygun tonsillektomi tekniğini tespit etmeyi amaçladık.Gereç ve Yöntem: Harran ...
Servet Erdemes, Alper Şen, Ahmet Yükkaldıran, Osman Erdoğan   +3 more
doaj   +1 more source

Perceived Impacts and Predictors of Cannabis Products Used by Patients with Rheumatologic Conditions in Alberta, Canada: A Multivariable Analysis of Cross‐Sectional Survey Data

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang, Samuel A.J. Lowe, Frank Sun, Allyson Jones, Tarek Turk, Joanne Olson, Pauline Paul, Shelby Yamamoto, Linda Kolewaski, Elaine Yacyshyn, Cheryl A. Sadowski   +10 more
wiley   +1 more source

A Scoping Review and Meta‐Analysis of Proportions of Central Nervous System Manifestations Reported in Patients with Sjögren's Disease

Arthritis Care &Research, Accepted Article.
Objective The objective of this scoping review was to synthesize evidence on the proportion of individuals living with Sjögren's disease who experience central nervous system (CNS) manifestations. Methods We searched MEDLINE (via PubMed) and Embase from 1980 through January 29, 2026, and the ECRI Guidelines Trust from 2020 through January 29, 2026 ...
Arun Varadhachary, Ghaith Noaiseh, Julie Frantsve‐Hawley, Frederick B. Vivino, Jennifer A. McCombe, Shamik Bhattacharyya, E. Sherwood Brown, Andrew R. Carey, Robert Fox, Thomas Grader‐Beck, Janet E. Lewis, Stephen Maitz, Steven Mandel, Astrid Rasmussen, George Sarka, R. Hal Scofield, Daniel J. Wallace, Rochelle Zak, Kristie Cox, Katherine M. Hammitt, Steven Carsons, Nancy Carteron   +21 more
wiley   +1 more source