Results 251 to 260 of about 799,321 (312)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Kangaroo mother care and maternal bonding 1 year after childbirth: a nationwide birth cohort-the Japan environment and children's cohort study. [PDF]

BMC Pregnancy Childbirth
Saito K, Inano H, Tsuchida A, Kasamatsu H, Sasano K, Shimada K, Matsumura K, Hamazaki K, Inadera H, Hasegawa T, Japan Environment, Children’s Study (JECS) Group.   +11 more
europepmc   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Machine learning-based early prediction of asthma in preschoolers: The COCOA birth cohort study. [PDF]

Pediatr Allergy Immunol
Han CH, Heo SJ, Jang H, Lee SY, Park JS, Suh DI, Shin YH, Kim J, Ahn K, Sohn MH, Choi EJ, Choi SH, Baek HS, Hong SJ, Kim KW, Jung I, Kim SY.   +16 more
europepmc   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

The KLOTHO Birth Cohort: Maternal and Neonatal Vitamin D Status and Neurodevelopmental Outcomes at 10 Years. [PDF]

Nutrients
Karras SN, Goulis DG, Kypraiou M, Harizopoulou V, Vlastos A, Anemoulis M, Tzimagiorgis G, Dalamaga M, Georgopoulos N, Kassi E, Mastorakos G, Makedou K, Skoutas D, Michalakis KG.   +13 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Maternal vitiligo is associated with increased autoimmune and atopic disease in offspring: A nationwide birth cohort study. [PDF]

JAAD Int
Kim HJ, Kim HS.
europepmc   +1 more source

Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort. [PDF]

BMC Res Notes
Keuss SE, Lu K, James SN, Nicholas JM, Coath W, Keshavan A, Cash DM, Sudre CH, Barnes J, Murray-Smith H, Wong A, Street R, Richards M, Schott JM.   +13 more
europepmc   +1 more source

Prenatal exposure to vanadium and lead and its impact on the risk of congenital heart defects in neonates: evidence from the Lanzhou Birth Cohort. [PDF]

Front Public Health
Wei Y, Sun J, Wu Z, Teng L, Huang J, Jiao X, Dang Y, Zhao X, Zhang Y, Tuo S, Mao B, Liu Q.   +11 more
europepmc   +1 more source