Results 231 to 240 of about 2,893,142 (314)

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Neuropsychiatric outcomes after montelukast versus inhaled corticosteroids in pediatric asthma: a pooled birth cohort study. [PDF]

BMC Med
Jiao XF, Ducharme FM, Leal LF, Longo C, Sheehy O, Kaguelidou F, Bérard A.   +6 more
europepmc   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

Prenatal exposure to acrylamide and neuropsychiatric disorders: a biomarker-based birth cohort study with 34 years of follow-up. [PDF]

EClinicalMedicine
Chandia-Poblete D, Tuffier S, Vryonidis E, Halldorsson TI, Bjerregaard AA, Strøm M, Rytter D, Bech BH, Henriksen TB, Olsen SF, Törnqvist M, Pedersen M.   +11 more
europepmc   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Effects of Age and Birth Cohort on Influenza A Virus Subtype-Specific Hospitalization Rates, United States, 2010-2025. [PDF]

J Infect Dis
O'Halloran A, Hood N, Ujamaa D, Merced-Morales A, Gurbaxani B, Kirley PD, Napoles MJ, Alden NB, Aragon D, Meek J, Yousey-Hindes K, Openo KP, Witt LS, Monroe ML, Ryan PA, Leegwater L, Rojewski S, Kenyon C, Lynfield R, Poblete M, Landis ZQ, Anderson BJ, Rowe AJ, Felsen CB, Tesini BL, Harbi K, Wilson E, Lung K, Moran NE, Sutton M, Thomas A, Talbot HK, Schaffner W, Crossland M, Olsen K, Patel M, Fry AM, Kondor R, Bozio C, Reed C, Brammer L, Budd A, Flannery B, Garg S.   +43 more
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Neurodevelopment of Children Exposed to HIV But Uninfected in Zambia: Outcomes From Prospective Birth Cohort Study. [PDF]

J Int AIDS Soc
Zulu EM, Rockers PC, Forman L, Musonda N, Nthele C, Shimaingwa F, Bartrum M, Kawama N, Masempela CB, Thea DM, Herlihy JM.   +10 more
europepmc   +1 more source