Results 241 to 250 of about 2,713,395 (314)

Taabo Multigenerational Birth Cohort in Côte d'Ivoire: Protocol for Establishing a Longitudinal Multigenerational Birth Cohort to Guide Health Policy. [PDF]

JMIR Res Protoc
Koné S, Probst-Hensch N, Dao D, Utzinger J, Laubet M, Tobo AM, Fink G.   +6 more
europepmc   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Changes in toothbrushing and factors associated with less than twice daily toothbrushing by the age of four in the FinnBrain Birth Cohort Study. [PDF]

Acta Odontol Scand
Suokko H, Tolvanen M, Virtanen J, Suominen A, Karlsson L, Karlsson H, Lahti S.   +6 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Steroid hormones in early pregnancy and adverse birth outcomes: a Chinese birth cohort. [PDF]

Front Endocrinol (Lausanne)
Wu W, Ji C, Li H, Diao F, Wu L, Ruan X, Luo Y, Luo M.   +7 more
europepmc   +1 more source

Soft, Multi‐Wavelength Photoplethysmography Enables Reliable Neonatal Blood Pressure Monitoring Via Error Stratification

Advanced Science, EarlyView.
A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi, Lanlan Mi, Jiarong Chen, Biao Liu, Min Wang, Zisheng Dai, Bin Liu, Ruize Gao, Yunfeng Lin, Weiwei Guo, Guoxing Wang, Wenyi Luo, Cheng Chen   +12 more
wiley   +1 more source

Home energy efficiency, overcrowding and lower respiratory tract infection admissions in infants: national birth cohort study in Scotland

Hart C, Rammah A, Riccio M, De Stavola B, Taylor J, Symonds P, Cunningham S, Dibben C, Swann O, Hajna S, Hardelid P.   +10 more
europepmc   +1 more source

Food introduction during the first year of life in a Swedish birth cohort - associations with allergy at 6 years of age. [PDF]

Nutr J
Stråvik M, Sandin A, Hesselmar B, Wold AE, Barman M, Sandberg AS.   +5 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Prenatal Exposure to Size-Fractionated Particulate Matter and Fetal Growth Trajectories: Mediation by Maternal Glucose Metabolism in a Birth Cohort. [PDF]

Toxics
Chen Q, Shi B, Liu Y, Wang X, Cai L, Cui Q, Tan X, Chen Y.   +7 more
europepmc   +1 more source