Results 221 to 230 of about 799,321 (312)

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

The impact of pediatric constipation on appendicitis: a prospective birth cohort in the Japan Environment and Children's Study. [PDF]

BMC Pediatr
Iwata H, Yamaguchi T, Itoh S, Ait Bamai Y, Ikeda A, Makino K, Itoh M, Tojo M, Yamamoto R, Tamura N, Ketema RM, Saijo Y, Ito Y, Kishi R, Japan Environment and Children’s Study (JECS) Group.   +14 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Gestational Hypertension as a Mediator of Prenatal Ozone Exposure and Term Low Birth Weight: Birth Cohort Study.

JMIR Public Health Surveill
Zhang Y, Liu Q, Song M, Huang Q, Zhao Q, Tao Q, Zhang C, Li Q, Wang Q.   +8 more
europepmc   +1 more source

Prenatal exposure to hyperglycemia and child growth trajectories in the first 3 years of life: a prospective birth cohort. [PDF]

BMC Med
Chen Y, Chi X, Wu S, Wei J, Yong Z, Lv H, Dou Y, Liu Y, Xu X, Qin R, Liu X, Han X, Xu B, Zhou K, Jiang Y, Jiang T, Ma H, Lin Y, Ye K, Hu Z, Du J, CNBC Group.   +21 more
europepmc   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Early-Life Exposures, Neurodevelopment, and Health Outcomes: Protocol for a Birth Cohort Study.

JMIR Res Protoc
Strand TA, Averina M, Bakken KS, Basnet S, Böttcher Y, Huber S, Hysing M, Kvestad I, Lüders T, McCann A, Pokhrel D, Ranjitkar S, Sharma AK, Shrestha M, Ulak M, Chandyo RK.   +15 more
europepmc   +1 more source

Cognitive dedifferentiation in later life: longitudinal findings from the Lothian Birth Cohort 1936. [PDF]

J Gerontol B Psychol Sci Soc Sci
Moodie JE, Corley J, Deary IJ, Cox SR.
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Body composition among 6-7 years-old children: data from the 2015 Pelotas (Brazil) Birth Cohort Study. [PDF]

BMC Pediatr
Flores TR, de Andrade Leão OA, Domingues MR, Hallal PC, da Silveira MF, Bertoldi AD.   +5 more
europepmc   +1 more source