Results 11 to 20 of about 2,117,831 (289)
BackgroundGenitourinary infections (GUIs) are common among sexually active women. Yet, little is known about the risk of birth defects associated with GUIs.MethodsUsing data from the National Birth Defects Prevention Study, a multisite, population-based,
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Birth Defects Res A Clin Mol Teratol [PDF]
BackgroundIn a recent study, high maternal periconceptional intake of vitamin E was found to be associated with risk of congenital heart defects (CHDs).
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Molecular Genetics & Genomic Medicine, 2019 Background Rubinstein–Taybi syndrome (RSTS) is a rare genetic disease characterized by broad thumbs and halluces, facial dysmorphisms, short stature, and intellectual disability.
Sha Yu +10 more
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Resveratrol’s neural protective effects for the injured embryoid body and cerebral organoid
BMC Pharmacology and Toxicology, 2022 Objective Resveratrol (RSV) is a polyphenol compound found in grapes, veratrum and other plants. It has been reported that RSV has anti-inflammatory, anti-oxidant, anti-cancer and other pharmacological effects.
Yanli Wang +5 more
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The changing epidemiology of syndactyly in Chinese newborns: a nationwide surveillance-based study
BMC Pregnancy and Childbirth, 2023 Background Little is known about the epidemiologic features of syndactyly (SD) in Chinese newborns. Methods Using 2007–2019 data from the Chinese Birth Defects Monitoring Network, we conducted a prevalence analysis on overall, isolated and associated ...
Zhi-Yu Chen +7 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
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High Expression of VAV Gene Family Predicts Poor Prognosis of Acute Myeloid Leukemia
Technology in Cancer Research & Treatment, 2021 Objectives: VAV family genes ( VAV1, VAV2, and VAV3 ) are associated with prognosis in various cancers; however, they have not been evaluated in acute myeloid leukemia (AML). In this study, the prognostic value of VAV expression in AML was evaluated by a
Dan Mu BA +3 more
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
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Inhibition of GOT1 potentiates ferroptosis and exacerbates cell death in acute myeloid leukemia
European Journal of Medical ResearchBackground Drug resistance, poor treatment response, and low long-term survival rates are major obstacles to the successful long-term treatment of acute myeloid leukemia (AML), a heterogeneous hematologic malignancy.
Huan Peng +7 more
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Frontiers in Immunology, 2022 IntroductionThe heterogeneity of treatment response in acute myeloid leukemia (AML) patients poses great challenges for risk scoring and treatment stratification. Carbohydrate metabolism plays a crucial role in response to therapy in AML.
You Yang +8 more
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