Results 21 to 30 of about 186,640 (311)

Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway

BMC Complementary Medicine and Therapies, 2022
Background Chronic myeloid leukemia (CML) is a myeloproliferative tumor originating from hematopoietic stem cells, and resistance to tyrosine kinase inhibitors (TKI) has become a major cause of treatment failure.
Xiang Qin, Xi Chen, Ling Guo, Jing Liu, You Yang, Yan Zeng, Cheng Li, Wenjun Liu, Wenzhe Ma   +8 more
doaj   +1 more source

Diabetes mellitus and birth defects [PDF]

American Journal of Obstetrics and Gynecology, 2008
The purpose of this study was to examine associations between diabetes mellitus and 39 birth defects.This was a multicenter case-control study of mothers of infants who were born with (n = 13,030) and without (n = 4895) birth defects in the National Birth Defects Prevention Study (1997-2003).Pregestational diabetes mellitus (PGDM) was associated ...
Adolfo, Correa, Suzanne M, Gilboa, Lilah M, Besser, Lorenzo D, Botto, Cynthia A, Moore, Charlotte A, Hobbs, Mario A, Cleves, Tiffany J, Riehle-Colarusso, D Kim, Waller, E Albert, Reece   +9 more
openaire   +2 more sources

Clinical exome sequencing identifies novel CREBBP variants in 18 Chinese Rubinstein–Taybi Syndrome kids with high frequency of polydactyly

Molecular Genetics & Genomic Medicine, 2019
Background Rubinstein–Taybi syndrome (RSTS) is a rare genetic disease characterized by broad thumbs and halluces, facial dysmorphisms, short stature, and intellectual disability.
Sha Yu, Bingbing Wu, Yanyan Qian, Ping Zhang, Yulan Lu, Xinran Dong, Qing Wang, Xuemei Zhao, Renchao Liu, Wenhao Zhou, Huijun Wang   +10 more
doaj   +1 more source

The changing epidemiology of syndactyly in Chinese newborns: a nationwide surveillance-based study

BMC Pregnancy and Childbirth, 2023
Background Little is known about the epidemiologic features of syndactyly (SD) in Chinese newborns. Methods Using 2007–2019 data from the Chinese Birth Defects Monitoring Network, we conducted a prevalence analysis on overall, isolated and associated ...
Zhi-Yu Chen, Wen-Yan Li, Wen-Li Xu, Yu-Yang Gao, Zhen Liu, Qi Li, Bin Yu, Li Dai   +7 more
doaj   +1 more source

Resveratrol’s neural protective effects for the injured embryoid body and cerebral organoid

BMC Pharmacology and Toxicology, 2022
Objective Resveratrol (RSV) is a polyphenol compound found in grapes, veratrum and other plants. It has been reported that RSV has anti-inflammatory, anti-oxidant, anti-cancer and other pharmacological effects.
Yanli Wang, Tingting Wei, Qiang Wang, Chaonan Zhang, Keyan Li, Jinbo Deng   +5 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Inhibition of GOT1 potentiates ferroptosis and exacerbates cell death in acute myeloid leukemia

European Journal of Medical Research
Background Drug resistance, poor treatment response, and low long-term survival rates are major obstacles to the successful long-term treatment of acute myeloid leukemia (AML), a heterogeneous hematologic malignancy.
Huan Peng, Fangshu Liu, Wenjue Tang, Xin Lin, Qiongyou Liang, Qinle Zhang, Huihong Dou, Sheng He   +7 more
doaj   +1 more source

High Expression of VAV Gene Family Predicts Poor Prognosis of Acute Myeloid Leukemia

Technology in Cancer Research & Treatment, 2021
Objectives: VAV family genes ( VAV1, VAV2, and VAV3 ) are associated with prognosis in various cancers; however, they have not been evaluated in acute myeloid leukemia (AML). In this study, the prognostic value of VAV expression in AML was evaluated by a
Dan Mu BA, Sili Long MA, Ling Guo PhD, Wenjun Liu MD   +3 more
doaj   +1 more source

Establishment and validation of a carbohydrate metabolism-related gene signature for prognostic model and immune response in acute myeloid leukemia

Frontiers in Immunology, 2022
IntroductionThe heterogeneity of treatment response in acute myeloid leukemia (AML) patients poses great challenges for risk scoring and treatment stratification. Carbohydrate metabolism plays a crucial role in response to therapy in AML.
You Yang, Yan Yang, Jing Liu, Yan Zeng, Qulian Guo, Jing Guo, Ling Guo, Haiquan Lu, Wenjun Liu   +8 more
doaj   +1 more source