Results 51 to 60 of about 2,070,255 (298)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Aberrant clones: Birth order generates life history diversity in Greater Duckweed, Spirodela polyrhiza

Ecology and Evolution, 2018
Environmental unpredictability is known to result in the evolution of bet‐hedging traits. Variable dormancy enhances survival through harsh conditions, and is widely cited as a diversification bet‐hedging trait.
Hebah S. Mejbel, Andrew M. Simons
doaj   +1 more source

Perception of family environment, sibling relationships, and life satisfaction: Effects of gender and birth order [PDF]

Zbornik Instituta za pedagoška istraživanja
The perception of early experiences in the family of origin and sibling relations can significantly shape life satisfaction. Considering the different roles influenced by birth order and gender, examining the predictive power of perceived family
Adamov Nikola, Prijić Jelena, Milovanović Ilija   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Fertility and the changing pattern of the timing of childbearing in Colombia

Demographic Research, 2016
Background: According to the latest 2010 CDHS, Colombia's total fertility rate (TFR) reached the level of 2.1. Studies show that the long-observed early childbearing pattern there might be changing, in particular for highly educated women, yet detailed ...
Ewa Batyra
doaj   +1 more source

Structural Relationships Between Assertiveness and Parenting Styles With Mediating Self-esteem and Anxiety of Singleton Children [PDF]

Iranian Rehabilitation Journal, 2022
Objectives: This study aimed to develop an explanatory model of assertiveness based on parenting styles mediated by anxiety and self-esteem. Methods: This study is descriptive-correlational modeling with partial least squares.
Reihaneh Rajabi Jourshari, Alireza Mohammadi Arya, Seyed Mohammadreza Alavizadeh, Somaye Entezari, Abbas Ali Hosseinkhanzadeh, Seyedeh Mahtab Amirizadeh   +5 more
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Unraveling the link between birth order and blood pressure: insights from a comprehensive systematic review and meta-analysis

FACETS
The objective of the present systematic review was to incorporate previous studies investigating the association of birth order with the risk of systolic and diastolic blood pressure (DBP).
Danial Habibi, Amir Hossein Koochekian, Hamid Reza Marateb, Homayoon masoudi, Hanifeh Mirtavoos-Mahyari, Muhammadhosein Moradi, Mahdi Akbarzadeh, Marjan Mansourian, Miguel Ángel Mañanas, Roya Kelishadi   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source