Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit+19 more
wiley +1 more source
Analysis of Birth weight using Singular Value Decomposition [PDF]
The researchers have drawn much attention about the birth weight of newborn babies in the last three decades. The birth weight is one of the vital roles in the babys health. So many researchers such as (2),(1) and (4) analyzed the birth weight of babies.
arxiv
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson+11 more
wiley +1 more source
Racial and Ethnic Patterning of Low Birth Weight, Normal Birth Weight, and Macrosomia [PDF]
Both low birthweight (4000 g) are considered adverse birth outcomes and are associated with later poor health conditions, yet the social determinants of macrosomia are understudied. In this study, we explore patterning of LBW, normal birthweight, and macrosomia by race/ethnicity and nativity.
Annie Ro+2 more
openaire +4 more sources
Monotone function estimation in the presence of extreme data coarsening: Analysis of preeclampsia and birth weight in urban Uganda [PDF]
This paper proposes a Bayesian hierarchical model to characterize the relationship between birth weight and maternal pre-eclampsia across gestation at a large maternity hospital in urban Uganda. Key scientific questions we investigate include: 1) how pre-eclampsia compares to other maternal-fetal covariates as a predictor of birth weight; and 2 ...
arxiv
Multivariate Meixner polynomials as Birth and Death polynomials [PDF]
Based on the framework of Plamen Iliev, multivariate Meixner polynomials are constructed explicitly as Birth and Death polynomials. They form the complete set of eigenpolynomials of a birth and death process with the birth and death rates at population $x=(x_1,\ldots,x_n)\in\mathbb{N}_0^n$ are $B_j(x)=\bigl(\beta+\sum_{i=1}^nx_j\bigr)$ and $D_j(x)=c_j^{
arxiv
HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang+11 more
wiley +1 more source
Pregnancy after liver transplantation with tacrolimus immunosuppression: A single center's experience update at 13 years [PDF]
Background. Chronic liver disease often leads to amenorrhea in women of childbearing age. There are several reports of successful pregnancy after liver transplantation (LTx) with cyclosporine A immunosuppression.
Armenti+20 more
core +1 more source
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy+14 more
wiley +1 more source
Prenatal Insecticide Exposures and Birth Weight and Length among an Urban Minority Cohort [PDF]
We reported previously that insecticide exposures were widespread among minority women in New York City during pregnancy and that levels of the organophosphate chlorpyrifos in umbilical cord plasma were inversely associated with birth weight and length ...
Andria Reyes+13 more
core +2 more sources