Results 181 to 190 of about 1,442,988 (353)

Precise Antigen-Antibody Structure Predictions Enhance Antibody Development with HelixFold-Multimer [PDF]

arXiv
The accurate prediction of antigen-antibody structures is essential for advancing immunology and therapeutic development, as it helps elucidate molecular interactions that underlie immune responses. Despite recent progress with deep learning models like AlphaFold and RoseTTAFold, accurately modeling antigen-antibody complexes remains a challenge due to
arxiv  

A recombinant bispecific single‐chain Fv antibody against HLA class II and FcγRIII (CD16) triggers effective lysis of lymphoma cells [PDF]

, 2004
Joerg Bruenke, Barbara Fischer, Karin Barbin, Katja Schreiter, Yvonne Wachter, Kerstin Mahr, Fritz Titgemeyer, Michael Niederweis, Matthias Peipp, Susan J. Zunino, Roland Repp, Thomas Valerius, Georg H. Fey   +12 more
openalex   +1 more source

Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX‐622

Allergy, EarlyView.
SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy, Laura Vitale, Thomas O'Neill, Deena M. Maurer, Linda Malenchek, Andrea Crocker, Colleen Patterson, Laura Mills‐Chen, Virginia Saley, Nicole M. Antczak, James M. Boyer, Kelly M. McManus, Noe Rico Montanari, Russell A. Hammond, Joel Goldstein, Lawrence J. Thomas, Tibor Keler, Diego Alvarado   +17 more
wiley   +1 more source

AlignAb: Pareto-Optimal Energy Alignment for Designing Nature-Like Antibodies [PDF]

arXiv
We present a three-stage framework for training deep learning models specializing in antibody sequence-structure co-design. We first pre-train a language model using millions of antibody sequence data. Then, we employ the learned representations to guide the training of a diffusion model for joint optimization over both sequence and structure of ...
arxiv  

Use of Bispecific Antibodies in Molecular Velcro Assays Whose Specificity Approaches the Theoretical Limit of Immunodetection for Bordetella pertussis [PDF]

, 2004
Xinling L. Tang, M S Peppler, Randall T. Irvin, M.R. Suresh   +3 more
openalex   +1 more source

Head‐To‐Head Comparison of Biologic Efficacy in Asthma: What Have We Learned?

Allergy, EarlyView.
ABSTRACT We performed an in‐depth appraisal of indirect head‐to‐head comparisons of biologics approved for asthma, including anti‐IL5/5Rα (mepolizumab, benralizumab), anti‐IL4Rα (dupilumab), anti‐TSLP (tezepelumab) and anti‐IgE (omalizumab), which was neither a systematic review nor a meta‐analysis.
Brian J. Lipworth, Robert Greig, Rory Chan, Chris RuiWen Kuo, Catherine Jackson   +4 more
wiley   +1 more source

Anti-Idiotype × Anti-CD44 Bispecific Antibodies Inhibit Invasion of Lymphoid Organs by B Cell Lymphoma [PDF]

, 2004
Esther Avin, Joseph Haimovich, Nurit Hollander   +2 more
openalex   +1 more source

In vitro comparison of CD20xCD3 biosimilar antibodies against diffuse large B‐cell lymphoma (DLBCL) cell lines with different levels of expression of CD20

British Journal of Haematology, EarlyView.
Summary Although CD20xCD3 bispecific antibodies (BsAbs) have demonstrated transformational activity in diffuse large B‐cell lymphoma (DLBCL), some patients fail to respond and others relapse. To begin to explore possible limitations, we compared the in vitro activity of four CD20xCD3 biosimilar BsAbs against four DLBCL cell lines with CD20 expression ...
Joshua S. Bray, Gethin R. Thomas, Victoria M. Smith, Adam Wright, Sandrine Jayne, Martin J. S. Dyer, Harriet S. Walter   +6 more
wiley   +1 more source

130. Targeting of Adenovirus Vectors to Mesothelin Via a Bispecific Antibody Reveals Enhanced Gene Transfer to Human Pancreatic Cancer Cells [PDF]

, 2004
MA van Geer, No Value Pastan, VW van Beusechem, Hidde J. Haisma, PJ Bosma, DJ Gouma, J. Wesseling   +6 more
openalex   +1 more source

Enterocolitis associated with glofitamab—First report and clinicopathological findings in three cases

British Journal of Haematology, EarlyView.
Summary Glofitamab is a CD3‐CD20 bispecific antibody used to treat B‐cell non‐Hodgkin lymphoma. We describe three cases of enterocolitis occurring with glofitamab at a single institution. Similarities between cases include onset post cycle 4–5, moderately elevated faecal calprotectin, abnormal bowel avidity on positron emission tomography scan (2/3 ...
Sean McKeague, Molly Robertson, Sam van der Linde, Christine Khoo, Jonathan Segal, Sean Harrop, Adrian Minson, Andrew W. Roberts, Michael Dickinson   +8 more
wiley   +1 more source