Results 191 to 200 of about 516,619 (288)

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

High-throughput engineering of bispecific antibodies to enhance macrophage-mediated cytotoxicity of B-cell lymphoma. [PDF]

Nat Commun
Pagès-Geli C, Ribeiro J, Wienclaw T, Meglan AM, Sloat L, Silva M, Blandin J, Velarde J, Vaccaro K, Sebastiany C, Fernández-Guzmán P, Hahn CK, Crespo M, Weiskopf K.   +13 more
europepmc   +1 more source

Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold, Chia Wei Cheah, Rathna Devi Vaithilingam   +2 more
wiley   +1 more source

Bispecific antibodies targeting herpes simplex virus glycoproteins B and D. [PDF]

Front Immunol
Atanasiu D, Saw WT, Cairns TM, Friedman HM, Cohen GH.   +4 more
europepmc   +1 more source

Physical Activity, Bleeding Incidence and Health‐Related Quality of Life, in Patients With Haemophilia A Without Inhibitors, Treated With Emicizumab: A Post‐Hoc Descriptive Analysis of the Power Study Data

Haemophilia, EarlyView.
Matteo Nicola Dario Di Minno, Berardino Pollio, Ezio Zanon, Gaetano Giuffrida, Sara Bendinelli, Raffaella Perrone, Giancarlo Castaman, the POWER study sites group   +7 more
wiley   +1 more source

Right dose, right patient: Clinician‐led implementation of a national cross‐specialty strategy for immunoglobulin stewardship

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Global demand for immunoglobulin (Ig) continues to rise, driven by expanding clinical indications and limited plasma supply. In England, use increased annually despite earlier demand‐management efforts, with substantial regional variation and prescribing for indications lacking evidence of benefit.
Claire Bethune, Michael P. Lunn, Mark Foster, Rob Hollingsworth, Darryn Boardman, Siraj A. Misbah   +5 more
wiley   +1 more source

The clinical trial landscape of bispecific antibodies in non-small cell lung cancer: mechanistic trends and developmental strategies. [PDF]

Front Pharmacol
Li Z, Wang X, Shi Q, Guo Y, Dong G, Liu Z.   +5 more
europepmc   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Transition from inpatient to outpatient step-up dosing of bispecific antibodies in multiple myeloma: real-world insights. [PDF]

Blood Adv
Manzato E, Puppi M, Barbato S, Vitale A, Sacchetti I, Masci S, Restuccia R, Ghibellini S, Pantani L, Mancuso K, Rizzello I, Talarico M, Cocchetto G, Terreo C, Iezza M, Cavo M, Zamagni E, Tacchetti P.   +17 more
europepmc   +1 more source