Results 201 to 210 of about 1,468,461 (396)

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Anti-CD3/Anti-Epidermal Growth Factor Receptor-Bispecific Antibody Retargeting of Lymphocytes against Human Neoplastic Keratinocytes in an Autologous Organotypic Culture Model [PDF]

, 2002
Isabelle Renard, Delia Mezzanzanica, Silvana Canevari, Silvano Ferrini, Jacques Boniver, Philippe Delvenne, Nathalie Jacobs   +6 more
openalex   +1 more source

Advanced single‐cell RNA sequencing in tumor immunology

Interdisciplinary Medicine, EarlyView.
This review highlights the applications of advanced single‐cell RNA sequencing (scRNA‐seq) technologies in tumor immunology. It summarizes representative scRNA‐seq methods according to technical principles, with a focus on single‐cell T cell receptor sequencing. This review also discusses how scRNA‐seq is used to construct immune cell atlases of tumors,
Yilong Liu, Xiyuan Yu, Zhipeng Han, Qiuyang Wei, Qi Niu, Chaoyong Yang, Jie P. Li, Zijian Guo, Huimin Zhang   +8 more
wiley   +1 more source

T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites [PDF]

, 2003
Shigeto Yoshida, Tominari Kobayashi, Hiroyuki Matsuoka, Chisato Seki, William L. Gosnell, Sandra P. Chang, Akira Ishii   +6 more
openalex   +1 more source

Recent Advancements in the Treatment of Age‐Related Macular Degeneration

Med Research, EarlyView.
ABSTRACT Age‐related macular degeneration (AMD) is a prevalent cause of visual impairment and blindness among the elderly. AMD can be categorized into two subtypes: “wet” and “dry.” Current treatments for wet AMD mainly involve anti‐vascular endothelial growth factor (VEGF) drugs, and there are three U.S.
Shan Liu, Danyang Lv, Junran Sun, Huixun Jia, Fang Zheng, Felipe Pereira, Siddharth Narendran, Zhenyu Dong, Haiyun Liu, Shunxiang Gao, Peirong Huang   +10 more
wiley   +1 more source

Phase I clinical trial of the bispecific antibody MDX-H210 (anti-FcγRI × anti-HER-2/neu) in combination with Filgrastim (G-CSF) for treatment of advanced breast cancer [PDF]

, 2003
Roland Repp, Heidi H. van Ojik, Thomas Valerius, Gerard Groenewegen, GABRIELE WIELAND, C Oetzel, Bernhard Stockmeyer, W. Becker, Michael Eisenhut, H Steininger, Yashwant M. Deo, G.H. Blijham, J. R. Kalden, Jan G. J. van de Winkel, Martin Gramatzki   +14 more
openalex   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Intradiabodies, Bispecific, Tetravalent Antibodies for the Simultaneous Functional Knockout of Two Cell Surface Receptors [PDF]

, 2003
Nina Jendreyko, Mikhail Popkov, Roger R. Beerli, Junho Chung, Dorian B. McGavern, Christoph Rader, Carlos F. Barbas   +6 more
openalex   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

A recombinant bispecific single‐chain antibody induces targeted, supra‐agonistic CD28‐stimulation and tumor cell killing [PDF]

, 2003
Ludger Große‐Hovest, Ingo Hartlapp, Wolfgang Marwan, Г. Брем, Hans‐Georg Rammensee, Gundram Jung   +5 more
openalex   +1 more source