Results 221 to 230 of about 44,321 (338)
T‐Cell–Redirecting Immunotherapies in Relapsed/Refractory Mantle Cell Lymphoma: Current Evidence, Sequencing, and Future Directions
European Journal of Haematology, Volume 116, Issue 2, Page 129-141, February 2026.ABSTRACT
Relapsed/refractory (R/R) mantle cell lymphoma (MCL) remains a therapeutic challenge, particularly in patients with high‐risk features or prior exposure to Bruton's tyrosine kinase inhibitors (BTKis). The advent of T‐cell–redirecting immunotherapies, including chimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific antibodies (BsAbs ...Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Massimo Gentile +10 morewiley +1 more sourceCorrection: Activity of CAR-T cells and bispecific antibodies in multiple myeloma with extramedullary involvement. [PDF]
Blood Cancer JSteinhardt MJ, Schaefers C, Leypoldt LB, Blau IW, Harzer M, Zhou X, Riedhammer C, Kamili A, Kosch R, Topp LS, Molwitz I, Gross-Fengels NO, Melzer YF, Artzenroth J, Al-Bazaz M, Alsdorf W, Topp MS, Duell J, Mersi J, Waldschmidt J, Bokemeyer C, Einsele H, Kortüm KM, Weisel K, Rasche L. +24 moreeuropepmc +1 more sourceIntegrated Imaging Probe and Bispecific Antibody Development Enables In Vivo Targeting of Glypican-3–Expressing Hepatocellular Carcinoma [PDF]
Peiman Habibollahi, Alexey Gurevich, James Z. Hui, Kelley Weinfurtner, George McClung, J Adler, Michael C. Soulen, David E. Kaplan, G. Nadolski, Stephen J. Hunt, Andrew Tsourkas, T. Gade +11 moreopenalex +1 more sourceAllogeneic haematopoietic cell transplant in cutaneous T‐cell lymphomas: Recommendations from the EBMT PH&G Committee
Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 174-184, February 2026.This EBMT Practice Harmonisation and Guidelines Committee consensus provides practical recommendations for the selection, timing and conduct of allogeneic transplantation in advanced‐stage mycosis fungoides and Sézary syndrome, aiming to optimize outcomes through early multidisciplinary collaboration and evidence‐based decision‐making.Gandhi Damaj, Adèle de Masson, Peter Dreger, Ali Bazarbachi, Philipp Berning, Rafael F. Duarte, Christopher P. Fox, Emmanuella Guenova, Olivier Hermine, Charalampia Kyriakou, Alina Tanase, Olivier Tournilhac, Wojiech Jurczak, Imke E. Karsten, Stéphanie Nguyen Quoc, Yasmina Serroukh, Federico Stella, Gerald Wulf, Anna Sureda, Evangelia Papadavid, Pablo L. Ortiz‐Romero, Annalisa Ruggeri, Isabel Sánchez‐Ortega, Julia J. Scarisbrick, Ibrahim Yakoub‐Agha, Francesco Onida, Norbert Schmitz +26 morewiley +1 more sourceCytomegalovirus reactivation during treatment with bispecific antibodies for relapsed/refractory multiple myeloma. [PDF]
Blood Cancer JJurgens E, Shekarkhand T, Rueda C, Nemirovsky D, Derkach A, Firestone RS, Miller K, Costa BA, Rajeeve S, Lesokhin AM, Korde N, Tan CR, Hashmi H, Hassoun H, Maclachlan K, Shah UA, Hultcrantz M, Hamadeh I, Giralt SA, Shah GL, Landau HJ, Scordo M, Usmani SZ, Mailankody S, Shahid Z. +24 moreeuropepmc +1 more sourceFigure S8 from A Novel Designed Anti–PD-L1/OX40 Bispecific Antibody Augments Both Peripheral and Tumor-Associated Immune Responses for Boosting Antitumor Immunity
Baocun Li, Shiyong Gong, Nianying Zhang, Beilei Shi, Zhou Lv, Yu Zhang, Naren Gaowa, Liqin Dong, Danqing Wu, Jianfu Wu, Fan Liu, Rui Zhang, Ramin Behzadigohar, Vinod Ganju, Chengbin Wu, Xuan Wu +15 moreopenalex +1 more sourceTherapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract
Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert +7 morewiley +1 more source1323 A novel bispecific antibody targeting CD137 and CLDN4 for treating patients with solid tumors [PDF]
Masahito Sato, Aya Kikuchi, Keita Nagaoka, Sumito Yoshida, Nicholas Souders, Masayasu Yoshino, Masayo Oishi, Hiroyuki Sayama, Takeshi Saito, Masashi Shimazaki, Kenna Shirasuna +10 moreopenalex +1 more sourceBi‐Functional Topospecific Nanoparticles to Promote Immune‐Tumor Cell Engagement as A New Immunotherapeutic Strategy
Advanced Materials, Volume 38, Issue 2, 8 January 2026.A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular, Alba Ortuño‐Bernal, Sandra Clara‐Trujillo, Elena Lucena‐Sánchez, Francisco J. Hicke, Andrea Escudero, Sandra Pradana‐López, Nelia Jiménez‐Alduan, Paula Díez, Alba García‐Fernández, Ramón Martínez‐Máñez +9 morewiley +1 more source