Results 31 to 40 of about 1,442,988 (353)

Risk of infections associated with the use of bispecific antibodies in multiple myeloma: a pooled analysis

Blood Advances, 2022
Key Points • Of the patients treated with BsAbs, half developed an infection, and a quarter developed grade III/IV infections.• BCMA-targeting BsAbs are associated with a higher risk of infection than non-BMCA–targeting BsAbs.
F. Mazahreh, L. Mazahreh, C. Schinke, S. Thanendrarajan, M. Zangari, J. Shaughnessy, F. Zhan, F. van Rhee, Samer Al Hadidi   +8 more
semanticscholar   +1 more source

Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models

mAbs, 2020
The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provide ...
Feng Wang, Jordan C. Tsai, Jonathan H. Davis, Bryant Chau, Jia Dong, Sean M. West, Jason M. Hogan, Matthew L. Wheeler, Christine Bee, Winse Morishige, Thomas Cayton, Donata David-brown, Chengyue Zhang, Alexander Kozhich, Tim Sproul, Gavin Dollinger, Arvind Rajpal, Pavel Strop   +17 more
doaj   +1 more source

Bispecific Antibodies in Cancer Immunotherapy: A Novel Response to an Old Question

Pharmaceutics, 2022
Immunotherapy has redefined the treatment of cancer patients and it is constantly generating new advances and approaches. Among the multiple options of immunotherapy, bispecific antibodies (bsAbs) represent a novel thoughtful approach.
C. Ordóñez-Reyes, J. Garcia-Robledo, D. Chamorro, Andrés Mosquera, Liliana Sussmann, A. Ruíz-Patiño, O. Arrieta, L. Zatarain-Barrón, L. Rojas, A. Russo, Diego de Miguel-Pérez, C. Rolfo, A. Cardona   +12 more
semanticscholar   +1 more source

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis

Fluids and Barriers of the CNS, 2022
Background Treatment with amyloid-β (Aβ) targeting antibodies is a promising approach to remove Aβ brain pathology in Alzheimer's disease (AD) and possibly even slow down or stop progression of the disease.
Ulrika Julku, Mengfei Xiong, Elin Wik, Sahar Roshanbin, Dag Sehlin, Stina Syvänen   +5 more
doaj   +1 more source

Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors

Journal for ImmunoTherapy of Cancer, 2022
Background Next-generation cancer immunotherapies are designed to broaden the therapeutic repertoire by targeting new immune checkpoints including lymphocyte-activation gene 3 (LAG-3) and T cell immunoglobulin and mucin-domain containing-3 (TIM-3).
Marina Natoli, K. Hatje, P. Gulati, F. Junker, P. Herzig, Zhi-wen Jiang, I. Davydov, M. Germann, M. Trüb, D. Marbach, Adrian Zwick, P. Weber, S. Seeber, M. Wiese, D. Lardinois, V. Heinzelmann-Schwarz, R. Rosenberg, L. Tietze, K. Mertz, P. Umaña, C. Klein, Laura Codarri-Deak, H. Kao, A. Zippelius   +23 more
semanticscholar   +1 more source

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Science Translational Medicine, 2021
Description Bispecific antibodies targeting multiple regions of the SARS-CoV-2 spike protein comparably neutralize variants of concern and wild-type virus.
Hyeseon Cho, K. K. Gonzales-Wartz, Deli Huang, M. Yuan, M. Peterson, Janie Y. Liang, N. Beutler, J. Torres, Yu Cong, E. Postnikova, S. Bangaru, C. A. Talana, W. Shi, E. Yang, Yi Zhang, K. Leung, Lingshu Wang, Linghang Peng, J. Skinner, Shanping Li, N. Wu, Hejun Liu, Cherrelle Dacon, Thomas Moyer, Melanie Cohen, Ming Zhao, F. Lee, R. Weinberg, I. Douagi, R. Gross, C. Schmaljohn, A. Pegu, J. Mascola, M. Holbrook, D. Nemazee, T. Rogers, A. Ward, I. Wilson, Peter D. Crompton, Joshua Tan   +39 more
semanticscholar   +1 more source

A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies

mBio, 2020
Broadly neutralizing antibodies (bNAbs) can prevent and control an HIV-1 infection, but their breadth is invariably too limited for use as monotherapy. To address this problem, bi- and trispecific antibody-like constructs have been developed.
Meredith E. Davis-Gardner, Barnett Alfant, Jesse A. Weber, Matthew R. Gardner, Michael Farzan   +4 more
doaj   +1 more source

Bispecific antibodies targeting mutant RAS neoantigens

Science immunology, 2021
Bispecific T cell–engaging antibodies capable of specifically killing cancer cells expressing mutant RAS neoantigens were generated. Diabodies see the unseeable RAS oncogene mutations are common in various cancers, controlling their growth and survival ...
J. Douglass, E. Hsiue, B. Mog, Michael S. Hwang, S. DiNapoli, Alexander H. Pearlman, Michelle S. Miller, Katharine M. Wright, P. Azurmendi, Qing Wang, S. Paul, A. Schaefer, A. Skora, M. Molin, M. Konig, Qiang Liu, E. Watson, Yana Li, Michael B. Murphy, D. Pardoll, C. Bettegowda, N. Papadopoulos, S. Gabelli, K. Kinzler, B. Vogelstein, Shibin Zhou   +25 more
semanticscholar   +1 more source

PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects

BioFactors, Volume 48, Issue 6, Page 1226-1249, November/December 2022., 2022
Abstract Ocular allergies are becoming more prevalent as more airborne pollutants, irritants and microbes pervade our environment. Inflammatory and allergic mediators released by dendritic and mast cells within the conjunctiva cause allergic conjunctivitis (AC), a prevalent ocular surface disorder that affects >40% of the world's human population on a ...
Najam A. Sharif
wiley   +1 more source

Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries

mAbs, 2021
Bispecific antibodies can uniquely influence cellular responses, but selecting target combinations for optimal functional activity remains challenging.
Pallavi Bhatta, Kevin D. Whale, Amy K. Sawtell, Clare L. Thompson, Stephen E. Rapecki, David A. Cook, Breda M. Twomey, Milena Mennecozzi, Laura E. Starkie, Emily M. C. Barry, Shirley J. Peters, Ahmad M. Kamal, Helene M. Finney   +12 more
doaj   +1 more source