Results 111 to 120 of about 98,296 (378)

Can we improve the prediction of hip fracture by assessing bone structure using shape and appearance modelling? [PDF]

, 2012
Copyright 2013 Elsevier B.V., All rights reserved.Peer ...
Alesci, S., Aspden, R. M., Barr, R. J., Goodyear, S. R., Gregory, J. S., McCloskey, E., Reid, D. M.   +6 more
core   +1 more source

Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporosis and fractures, and denosumab, a non‐kidney‐excreted antiresorptive medication, represents a viable alternative to bisphosphonates for osteoporosis treatment in patients with T2DM. This study aimed to investigate the association among denosumab adherence, renal
Yu‐Chuan Chang, Jian‐Chih Chen, Sung‐Yen Lin, Kun‐Der Lin, Pei‐Shan Ho, Chung‐Hwan Chen, Yin‐Chih Fu, Tien‐Ching Lee   +7 more
wiley   +1 more source

Bisphosphonate use in patients undergoing total knee arthroplasty reduces overall and aseptic revisions and periprosthetic bone mineral density loss: A systematic review from the FP‐UCBM Knee Study Group

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
ABSTRACT Purpose Bisphosphonates (BPs), widely used for osteoporosis management, have garnered attention in the context of total knee arthroplasty (TKA) for their potential to preserve periprosthetic bone mineral density (BMD) and mitigate risks such as aseptic loosening, periprosthetic fractures, and implant failure. This study systematically reviewed
Giancarlo Giurazza, Marco Edoardo Cardinale, Edoardo Franceschetti, Stefano Campi, Giuseppe Francesco Papalia, Pietro Gregori, Francesco Rosario Parisi, Augusto Ferrini, Michele Paciotti, Rocco Papalia   +9 more
wiley   +1 more source

Bisphosphonates

, 2014
Over the 40-year period during which bisphosphonates have been used in clinical practice, the mechanism of action for both simple and nitrogen-containing compounds has become clear, although sources variation in individual response still requires further investigation.
Bishop, N, Russell, G
openaire   +2 more sources

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Older people and medication taking behaviour: A review of the literature [PDF]

, 2008
Background: Older people represent a sizeable population of the UK. Many older people receive drug treatment for long term conditions. Adherence with medication is therefore an important clinical, financial and resource intensive concern.
Barber, Belcher, Benson, Benson, Blaxter, Bonner, Butler, Campbell, Carr, Chen, Chin, Cline, Cohen, Conrad, Corlett, De Geest, Dowell, Dunbar-Jacob, Ekman, Griffiths, Harrison, Hughes, Johnson, Kippen, Kjellgren, Kjellgren, Kripalani, Lee, Leventhal, Levy, Lumme-Sandt, Maggi Banning, Maidment, Mallion, Mancia, Mays, McElnay, Phatak, Pound, Pound, Roth, Sackett, Salas, Sale, Scotto, Senior, Struthers, Svensson, Unson, Van der Wal, Veehof, Vermiere, Watson, Zafran   +53 more
core   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Increased fracture rate in women with breast cancer: a review of the hidden risk

BMC Cancer, 2011
Background Women with breast cancer, particularly individuals diagnosed at a relatively early age, have an increased incidence of fractures. Fractures can have serious clinical consequences including the need for major surgery, increased morbidity and ...
Body Jean-Jacques
doaj   +1 more source

What do we know about atypical femoral fractures? Insights and enigmas [PDF]

, 2011
Although the existence of atypical femoral fractures is well established and bisphosphonate therapy is thought to be a major risk factor, the underlying mechanisms are poorly understood.
B. Cortet, M. Audran, T. Thomas
core   +3 more sources

Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications

ChemistryOpen, EarlyView.
This review highlights the emerging applications of molecularly imprinted polymers (MIPs) in bone regeneration and diagnosis. MIPs facilitate osteogenic treatments by guiding stem cell differentiation and delivering bioactive molecules and enable precise detection of bone turnover biomarkers via MIP‐based sensors, offering promising strategies for next‐
Ren Yang, Xiaohan Ma, Mingcheng Xuan, Yingqi Ma, Jiexian Ding, David Y. S. Chau, Jonathan C. Knowles, Feng Peng, Alessandro Poma   +8 more
wiley   +1 more source