ABSTRACT Introduction Medication‐Related Osteonecrosis of the Jaw (MRONJ) is a severe adverse effect of antiresorptive and antiangiogenic treatment, primarily in osteoporotic and oncologic patients. The disease is characterized by persistent jawbone necrosis that results in significant impairment of the quality of life of involved patients.
Omar Ghanaiem +2 more
wiley +1 more source
ABSTRACT Background Identification of healthy bone margins is a critical step in the surgical resective treatment of medication‐related osteonecrosis of the jaw (MRONJ). Fluorescence‐guided surgery (FGS) has been proposed as a method to identify resection margins and improve clinical outcomes.
Paolo De Angelis +6 more
wiley +1 more source
Current perspectives on bisphosphonate treatment in Paget’s disease of bone
Winnie Zee Man Wat Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong Abstract: Paget’s disease of bone is a chronic metabolic bone disease with focal increase in bone turnover.
Wat WZM
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Investigation of Bisphosphonate Therapy for Osteoporosis: A Single-Center Cross-Sectional Study. [PDF]
Harada T, Kosaka S.
europepmc +1 more source
Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park +5 more
wiley +1 more source
Intralesional Triamcinolone versus Oral Bisphosphonate for Benign Cystic Bone Lesions: A Prospective Comparative Study of Radiological and Pain Outcomes. [PDF]
Kalme B, Kumar A, Gupta RK.
europepmc +1 more source
Oral Health Screening Prior to Oncological Treatment—The Helsinki Protocol
ABSTRACT Objectives Oncological treatments can have adverse effects on oral health and cause long‐term complications such as osteonecrosis. This retrospective study investigated the oral health of head and neck cancer patients before radiotherapy and patients with multiple myeloma, breast, prostate, lung, and kidney cancers before antiresorptive ...
Jemina Järvinen +4 more
wiley +1 more source
Comments on 'Bisphosphonate and statin: adverse effects of co-medication on wound healing in in vitro models of periodontal tissues'. [PDF]
Szaraz D +2 more
europepmc +1 more source
ABSTRACT Objectives To determine whether pretreatment radiomics can predict medication‐related osteonecrosis of the jaw (MRONJ). Methods Patients with mandibular MRONJ at Hiroshima University Hospital (2009–2024) who underwent MDCT before initiating bone resorption inhibitors were retrospectively identified. Records from 2009 to 2020 were also reviewed
Masaru Konishi
wiley +1 more source
Oral bisphosphonates and risk of incident osteoarthritis in individuals with osteoporosis: a target trial emulation. [PDF]
Hatano M +7 more
europepmc +1 more source

