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Dentistry Journal, 2023 Osteonecrosis of the jaw is a condition in which bone cells die due to various causes. It is classified as drug-induced jaw osteonecrosis, osteoradionecrosis, traumatic, non-traumatic, and spontaneous osteonecrosis. Antiresorptive or antiangiogenic drugs
Božana Lončar Brzak +6 more
doaj +7 more sources
Japanese Dental Science Review, 2019 Summary: Since Marx reported on osteonecrosis of the jaw caused by the injectable bisphosphonates (BPs) pamidronate and zoledronate, there have been numerous reports not only in Western countries, but in Japan as well, of bisphosphonate-related ...
Takahiko Shibahara
exaly +3 more sources
Low awareness of medication-related osteonecrosis of the jaw among dentists: a systematic review with a medical and bioethical perspective [PDF]
BMC Medical EthicsIntroduction Medication-related osteonecrosis of the Jaw (MRONJ) is a serious adverse drug reaction that can seriously affect the quality of life of patients if not promptly diagnosed and treated. To date, preventive measures have been the most effective
Martina Coppini +4 more
doaj +2 more sources
Osteonecrosis of the Jaw [PDF]
Journal of Oncology Practice, 2006 This review looks at osteonecrosis in the stomatognathic system (mainly the jaws). Osteonecrosis of the jaw (ONJ) is a rare but serious clinical condition. It affects patients treated with bisphosphonates, and also with denosumab, mainly in oncological doses. In osteoporosis, it is a problem of relatively small significance. Article presents a thorough
Catherine Van Poznak, Brent B Ward
openaire +3 more sources
Applied Sciences, 2022 Osteonecrosis of the jaw represents interference by external and internal factors in the natural bone remodeling system. Numerous bone remodeling agents (BMAs), such as bisphosphonates, denosumab, and tyrosine kinase inhibitors, can lead to medication ...
Mihai Vlad Golu +6 more
doaj +1 more source
São Paulo Medical Journal, 2020 BACKGROUND: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is still the most prevalent type of osteonecrosis with clinical relevance. In Brazil, bisphosphonate use is high but there is a lack of epidemiological studies on BRONJ. OBJECTIVE: To
Aloizio Premoli Maciel +4 more
doaj +1 more source
Clinical Case Reports, 2023 Key Clinical Message Chronic use of bisphosphonates, in combination with immunosuppressive therapy, increases the risk of jaw osteonecrosis. When sepsis occurs in patients receiving bisphosphonate, osteonecrosis of the jaw should be considered a ...
Kazuhiko Iwasaki, Akihito Okazaki
doaj +1 more source
Updates on osteonecrosis of the jaw [PDF]
Current Opinion in Supportive & Palliative Care, 2010 Osteonecrosis of the jaw (ONJ) is an uncommon condition noted to occur in patients with cancer who are receiving intravenous bisphosphonates. The cause of ONJ remains unknown. The leading hypotheses addressing the mechanism of ONJ are reviewed here.The present clinical data suggest that ONJ may occur in approximately 5% of patients with metastatic bone
Junro, Yamashita +2 more
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Frontiers in Endocrinology, 2021 BackgroundA causal relationship of bisphosphonate (BP) exposure with osteonecrosis of the jaw (ONJ) has been reported; however, a definite dose-dependent risk remains to be elucidated beyond current vague recommendations of 4-year oral BP for ONJ risk ...
Jung-Hyun Park +6 more
doaj +1 more source
Brazilian Journal of Otorhinolaryngology, 2022 Introduction: Increased incidence of localized osteonecrosis in the jaw bones caused by bisphosphanate use and reduced quality of life of the patients led researchers to diagnose the disease in the early period and to investigate the effective treatment ...
Onur Şahin +5 more
doaj +1 more source