Results 11 to 20 of about 26,607 (119)

Medication‐related osteonecrosis of the jaw leading to sepsis in a patient with rheumatoid arthritis: A case report and clinical implications

Clinical Case Reports, 2023
Key Clinical Message Chronic use of bisphosphonates, in combination with immunosuppressive therapy, increases the risk of jaw osteonecrosis. When sepsis occurs in patients receiving bisphosphonate, osteonecrosis of the jaw should be considered a ...
Kazuhiko Iwasaki, Akihito Okazaki
doaj   +1 more source

Can Anti-Tumor Necrosis Factor Agents Be Discontinued in Patients with Inflammatory Bowel Disease?

Gut and Liver, 2021
Background/Aims: Bisphosphonates are increasingly recognized for their anti-neoplastic properties, which are the result of their action on the mevalonate pathway.
Jihye Park, Jae Hee Cheon
doaj   +1 more source

Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study

Maxillofacial Plastic and Reconstructive Surgery, 2019
Background Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition.
Jae-Young Kim, Dae-Hoon Kim, Hyo-Won Jang, Kwang-Ho Park, Jong-Ki Huh   +4 more
doaj   +1 more source

Regioselective ester cleavage during the preparation of bisphosphonate methacrylate monomers

Beilstein Journal of Organic Chemistry, 2011
New functional monomers bearing a methacrylate, a bisphosphonate function and, for most, an internal carboxylate group, were prepared for incorporation into copolymers with adhesive or anticorrosive properties.
Kamel Chougrani, Gilles Niel, Bernard Boutevin, Ghislain David   +3 more
doaj   +1 more source

Bisphosphonate-associated Osteonecrosis of the Jaws: a Survey of the Level of Knowledge of Dentists about the Risks of Bisphosphonate Therapy

Folia Medica, 2019
Introduction: Bisphosphonate-associated osteonecrosis of the jaws (BAONJ) is a side effect of treatment with bisphosphonate (BP). Reports of this complication have increased recently.
Hristamyan-Cilev Meri A., Pechalova Petya P., Raycheva Ralitsa D., Hristamyan Veselka P., Kevorkyan Ani K., Stoilova Yordanka D.   +5 more
doaj   +1 more source

The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection

mBio, 2022
Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation, as well as longer ...
Melissa A. Sleda, Zhu-Hong Li, Ranjan Behera, Baihetiya Baierna, Catherine Li, Jomkwan Jumpathong, Satish R. Malwal, Makoto Kawamukai, Eric Oldfield, Silvia N. J. Moreno   +9 more
doaj   +1 more source

Bisphosphonate conjugation for bone specific drug targeting

Bone Reports, 2018
Bones provide essential functions and are sites of unique biochemistry and specialized cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has presented difficulties in the past, and improved delivery of drugs to bone ...
Kristen B. Farrell, Alexander Karpeisky, Douglas H. Thamm, Shawn Zinnen   +3 more
doaj   +1 more source

The establishment of a bisphosphonate⁃related osteonecrosis of the jaw rat model

口腔疾病防治, 2017
With the wide use of bisphosphonates in bone diseases such as osteoporosis and bone metastases of ma⁃ lignant tumors, bisphosphonate⁃related osteonecrosis of the jaw has gained widely attention as a severe side effect. Ani⁃ mal model is a useful way to
LIU Jie, TANG Hua
doaj   +1 more source

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

Antibiotics, 2021
The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about Staphylococcus aureus colonization of the osteocyte-lacuno canalicular network (OLCN).
Emmanuela Adjei-Sowah, Yue Peng, Jason Weeks, Jennifer H. Jonason, Karen L. de Mesy Bentley, Elysia Masters, Yugo Morita, Gowrishankar Muthukrishnan, Philip Cherian, X. Eric Hu, Charles E. McKenna, Frank H. Ebetino, Shuting Sun, Edward M. Schwarz, Chao Xie   +14 more
doaj   +1 more source

Four-Year Teriparatide Followed by Denosumab vs. Continuous Denosumab in Glucocorticoid-Induced Osteoporosis Patients With Prior Bisphosphonate Treatment

Frontiers in Endocrinology, 2021
ObjectivesIn our previous 24-month study, we observed that teriparatide had some advantages over denosumab for bone mineral density (BMD) in glucocorticoid-induced osteoporosis (GIO) patients with prior bisphosphonate treatment.
Yasuaki Hirooka, Yasuaki Hirooka, Yuji Nozaki, Saki Okuda, Masafumi Sugiyama, Koji Kinoshita, Masanori Funauchi, Itaru Matsumura   +7 more
doaj   +1 more source