Results 41 to 50 of about 34,707 (260)

A brief review and clinical evidences of teriparatide therapy for atypical femoral fractures associated with long-term bisphosphonate treatment

Frontiers in Surgery, 2023
The risk of bisphosphonate (BP)-associated atypical femur fracture (AFF) has markedly increased over recent decades due to suppression of bone turnover, accumulation of structural micro-damage and reduction of bone remodeling consequent to long-term BP ...
Jianpeng Gao, Jianpeng Gao, Xiao Liu, Xiao Liu, Xiaoyong Wu, Xiaoya Li, Jianheng Liu, Jianheng Liu, Ming Li, Ming Li   +9 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Bisphosphonate-related bilateral atypical femoral fractures : be aware and beware [PDF]

, 2011
Although bisphosphonates have a well established therapeutic role in the prevention of osteoporosis-related fractures, several reports published over the past 5-6 years suggest a possible causative relationship between long-term use of bisphosphonates ...
Depasquale, Ruben, Matthews, Claire, Cassar-Pullicino, Victor N.   +2 more
core  

Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways

, 2018
Bisphosphonates are a major class of drugs used to treat osteoporosis, Paget’s disease, and cancer. They have been proposed to act by inhibiting one or more targets including protein prenylation, the epidermal growth factor receptor, or the adenine ...
Boo Kyung Kim (3077706), Xinxin Feng (553655), Noman Baig (3077709), Jiaqi Yao (235055), Eric Oldfield (558367), Rahul L. Khade (1372551), Petri Turhanen (1622155), Christopher Shin (5340848), Yong Zhang (5893), Satish R. Malwal (5340851), Bing O’Dowd (2545582), Tianhui Zhou (2834852), Sandhya Bansal (1910197)   +12 more
core   +1 more source

Clinical and CBCT assessment of role of bisphosphonate on osteotomy site and implant surface

Journal of Pharmacy and Bioallied Sciences
Objectives: To assess the role of bisphosphonate on osteotomy site and implant surface. Materials and Methods: Twenty patients with adequate width and height of edentulous space and a single missing posterior tooth between the ages of 25 and 55 were ...
Amit Singh, A Muthukumarswamy, George Attokaran, Mirna Garhnayak, Lokanath Garhnayak, Lipika Gopal, Naveen Reddy   +6 more
doaj   +1 more source

Bisphosphonates May Reduce Intraoperative Blood Loss in Surgery for Metastatic Spinal Disease: A Retrospective Cohort Study

Clinical Interventions in Aging, 2021
Hao-Ran Zhang,1,* Yun-Long Zhao,1,* Rui-Qi Qiao,2 Ji-Kai Li,2 Yong-Cheng Hu1 1Department of Bone Tumor, Tianjin Hospital, Tianjin, People’s Republic of China; 2Graduate School, Tianjin Medical University, Tianjin, People’s Republic of China&ast ...
Zhang HR, Zhao YL, Qiao RQ, Li JK, Hu YC
doaj  

Clinical features of atypical femur fracture

Osteoporosis and Sarcopenia, 2016
Objectives: We aim to elucidate the clinical outcomes of bisphosphonate-associated atypical femoral fracture and the clinical results depending on the bisphosphonate therapy period.
Joong Sup Shin, Nak Chul Kim, Kyoung Ho Moon   +2 more
doaj   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Short-term Bisphosphonate use associated stress fractures [PDF]

, 2022
Introduction: Long-term bisphosphonate use has been linked to an increased risk of pathological neck of femur fractures. Case report: We write concerning a patient who presented with the left hip pain following a low impact fall, which was diagnosed as ...
Anakwe, Raymond, Dadrewalla, Arshan, Battle, Joseph   +2 more
core   +1 more source