Results 51 to 60 of about 89,117 (340)

Clinical and biochemical response to neridronate treatment in a patient with osteoporosis-pseudoglioma syndrome (OPPG) [PDF]

, 2017
Osteoporosis-pseudoglioma syndrome (OPPG) is a rare autosomal recessive syndrome characterized by juvenile-onset osteoporosis and ocular abnormalities due to a low-density lipoprotein receptor-related protein 5 (LRP5) gene mutation.
Celli, L, Celli, M., D'Alfonso, Y, D'Eufemia, P, Febbo, A, Persiani, P, Turchetti, A., Zambrano, A   +7 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Anti‐Osteoporosis Medications Associated with Decreased Mortality after Hip Fracture

Orthopaedic Surgery, 2019
Objective To study the effect of anti‐osteoporosis therapies on mortality after hip fracture. Methods This retrospective study was carried out in the Second Affiliated Hospital of Fujian Medical University and enrolled 690 patients 50 years of age and ...
Pei‐wen Wang, Yi‐zhong Li, Hua‐feng Zhuang, Hai‐ming Yu, Si‐qing Cai, Hao Xu, Zhen‐hui Chen, Jin‐kuang Lin, Xue‐dong Yao   +8 more
doaj   +1 more source

Proximal femoral reconstruction for failed internal fixation of a bisphosphonate-related femur fracture

Arthroplasty Today, 2016
We present a case of a bisphosphonate-related femur fracture in an elderly woman, who failed treatment with both cephalomedullary nail and proximal femoral locking plate, leading to successful treatment with total hip arthroplasty.
Rishabh G. Jethanandani, BSE, Chima Nwankwo, MD, Philip R. Wolinsky, MD, Mauro Giordani, MD, Derek F. Amanatullah, MD, PhD   +4 more
doaj   +1 more source

A brief review and clinical evidences of teriparatide therapy for atypical femoral fractures associated with long-term bisphosphonate treatment

Frontiers in Surgery, 2023
The risk of bisphosphonate (BP)-associated atypical femur fracture (AFF) has markedly increased over recent decades due to suppression of bone turnover, accumulation of structural micro-damage and reduction of bone remodeling consequent to long-term BP ...
Jianpeng Gao, Jianpeng Gao, Xiao Liu, Xiao Liu, Xiaoyong Wu, Xiaoya Li, Jianheng Liu, Jianheng Liu, Ming Li, Ming Li   +9 more
doaj   +1 more source

Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort [PDF]

, 2018
Background: Several different classes of medications have been shown to be efficacious at preventing fractures in patients with osteoporosis. No study has compared real world efficacy at preventing fractures between all currently approved medications ...
Fox, Edward J., Kocis, Paul T., Leslie, Douglas L., Liu, Guodong, Reynolds, Alan W., Skowronski, Jenna N.   +5 more
core   +2 more sources

Role of Prednisone and 25‐Hydroxyvitamin D on Bone Mineral Density and Osteoporosis in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We evaluated the role of 25‐hydroxyvitamin D (25[OH]D), prednisone, and other risk factors for bone mineral density (BMD) loss and osteoporosis in systemic lupus erythematosus (SLE). Methods We calculated the association between 25(OH)D levels and other potential risk factors and BMD measures (spine T scores) and osteoporosis (defined as a T ...
Nima Madanchi, Andrea Fava, Daniel W. Goldman, Laurence S. Magder, Michelle Petri   +4 more
wiley   +1 more source

Increasing the knowledge, identification and treatment of osteoporosis through education and shared decision-making with residents living in a retirement village community [PDF]

, 2018
Objective: This pilot study explored whether individual goal setting in a retirement village setting could improve strategies to strengthen bones in an ageing population and help prevent osteoporosis.
Australian Institute of Health and Welfare, Bender, Blalock, Center, Chami, Commonwealth of Australia, Dreinhöfer, Ebeling, Farmer, Francis, Gaines, Gianoudis, Hosking, Iversen, Levinson, Nanduri, Nayak, Nielsen, Otmar, Pasco, Rothmann, Sale, The Royal Australian College of General Practitioners, Tosi, Watts, Winzenberg   +25 more
core   +2 more sources

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

The dental management of patients at risk of medication-related osteonecrosis of the jaw: New paradigm of primary prevention [PDF]

, 2018
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is a potentially painful and debilitating condition that can considerably affect the quality of life of patients ...
Bedogni, Alberto, Campisi, Giuseppina, Di Fede, Olga, Fusco, Vittorio, Lo Muzio, Lorenzo, Mauceri, Rodolfo, Panzarella, Vera, Sipmo Onj Board, Null   +7 more
core   +2 more sources