Results 41 to 50 of about 98,296 (378)

The establishment of a bisphosphonate⁃related osteonecrosis of the jaw rat model

口腔疾病防治, 2017
With the wide use of bisphosphonates in bone diseases such as osteoporosis and bone metastases of ma⁃ lignant tumors, bisphosphonate⁃related osteonecrosis of the jaw has gained widely attention as a severe side effect. Ani⁃ mal model is a useful way to
LIU Jie, TANG Hua
doaj   +1 more source

Patient level pooled analysis of 68,500 patients from seven major vitamin D fracture trials in the US and Europe [PDF]

, 2010
Objectives To identify participants’ characteristics that influence the anti-fracture efficacy of vitamin D or vitamin D plus calcium with respect to any fracture, hip fracture, and clinical vertebral fracture and to assess the influence of dosing ...
Abrahamsen, B, Anderson, F, Avenell, A, Brixen, K, Cooper, C, F, Hutchison, Francis, R M, Jackson, R, Johansen, A, LaCroix, A Z, Masud, T, Meyer, H E, Mosekilde, L, Rejnmark, L, Robbins, J A, Smith, H, The DIPART (vitamin D Individual Patient Analysis of Randomized Trials) Group, Torgerson, D, Wactawski-Wende, J   +18 more
core   +2 more sources

Risk of atypical femoral fracture during and after bisphosphonate use

Acta Orthopaedica, 2015
Background and purpose — Use of bisphosphonates in women is associated with higher risk of atypical femoral fractures. The risk in terms of timing of use and type of bisphosphonate, and in men, remains unclear.
J. Schilcher, Veronika Koeppen, P. Aspenberg, K. Michaëlsson   +3 more
semanticscholar   +1 more source

Bisphosphonates: An update

Journal of Pharmacy And Bioallied Sciences, 2012
Bisphosphonates are used widely for variety of bone condition, most notably IV bisphosphonates in the treatment of metastic bone lesion and oral bisphosphonates for osteoporosis. They constitute a group of drugs capable of modulating bone turnover and reducing its remodeling when an excessive resorption occurs.
Subramanium Gokulnathan, Nalliappan Ganapathy, Venkatesan, Nataraj Balan, Thangadurai Maheswaran   +4 more
openaire   +4 more sources

Increasing the knowledge, identification and treatment of osteoporosis through education and shared decision-making with residents living in a retirement village community [PDF]

, 2018
Objective: This pilot study explored whether individual goal setting in a retirement village setting could improve strategies to strengthen bones in an ageing population and help prevent osteoporosis.
Australian Institute of Health and Welfare, Bender, Blalock, Center, Chami, Commonwealth of Australia, Dreinhöfer, Ebeling, Farmer, Francis, Gaines, Gianoudis, Hosking, Iversen, Levinson, Nanduri, Nayak, Nielsen, Otmar, Pasco, Rothmann, Sale, The Royal Australian College of General Practitioners, Tosi, Watts, Winzenberg   +25 more
core   +2 more sources

Pharmacology of bisphosphonates [PDF]

British Journal of Clinical Pharmacology, 2019
The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone resorption were first described in the late 1960s. In the 50 years that have elapsed since then, the BPs have become the leading drugs for the treatment of skeletal disorders characterized by increased bone resorption, including Paget's disease of bone, bone ...
Matthew T. Drake, F. Hal Ebetino, F. Hal Ebetino, Serge Cremers, John P. Bilezikian, R. Graham G. Russell, R. Graham G. Russell   +6 more
openaire   +3 more sources

Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties

Scientific Reports, 2017
Osteoporosis is characterised by trabecular bone loss resulting from increased osteoclast activation and unbalanced coupling between resorption and formation, which induces a thinning of trabeculae and trabecular perforations.
Shaocheng Ma, E. L. Goh, A. Jin, R. Bhattacharya, Oliver R. Boughton, B. Patel, A. Karunaratne, Nghia T. Vo, R. Atwood, J. Cobb, U. Hansen, R. Abel   +11 more
semanticscholar   +1 more source

A brief review and clinical evidences of teriparatide therapy for atypical femoral fractures associated with long-term bisphosphonate treatment

Frontiers in Surgery, 2023
The risk of bisphosphonate (BP)-associated atypical femur fracture (AFF) has markedly increased over recent decades due to suppression of bone turnover, accumulation of structural micro-damage and reduction of bone remodeling consequent to long-term BP ...
Jianpeng Gao, Jianpeng Gao, Xiao Liu, Xiao Liu, Xiaoyong Wu, Xiaoya Li, Jianheng Liu, Jianheng Liu, Ming Li, Ming Li   +9 more
doaj   +1 more source

Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort [PDF]

, 2018
Background: Several different classes of medications have been shown to be efficacious at preventing fractures in patients with osteoporosis. No study has compared real world efficacy at preventing fractures between all currently approved medications ...
Fox, Edward J., Kocis, Paul T., Leslie, Douglas L., Liu, Guodong, Reynolds, Alan W., Skowronski, Jenna N.   +5 more
core   +2 more sources

Bisphosphonates and atrial fibrillation: Bayesian meta-analyses of randomized controlled trials and observational studies

BMC Musculoskeletal Disorders, 2009
Background Occurrence of atrial fibrillation (AF) amongst bisphosphonate users has been increasingly reported but results are conflicting. We performed a Bayesian meta-analysis to address the possible association between the occurrence of AF and ...
Cheak Alicia, Ho Roger, Cheung Mike WL, Mak Anselm, Lau Chak   +4 more
doaj   +1 more source