Results 71 to 80 of about 66,822 (310)

Coping with complexity: working beyond the guidelines for patients with multimorbidities [PDF]

, 2015
Primary care physicians believe they are delivering evidence-based care, understanding that adherence to evidence-based clinical guidelines results in tangible benefits in the populations for which they were developed.
Treadwell, Julian
core   +3 more sources

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, EarlyView.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

Role of Teriparatide in Medication-Related Osteonecrosis of the Jaws (MRONJ)

Dentistry Journal, 2016
While the optimal treatment concept of medication-related osteonecrosis of the jaws (MRONJ) is still in debate, several adjunct therapies have been introduced.
Yong-Dae Kwon, Deog-Yoon Kim
doaj   +1 more source

Structure-Dependent Effects of Bisphosphonates on Inflammatory Responses in Cultured Neonatal Mouse Calvaria

Antioxidants, 2020
Bisphosphonates (BPs) are classified into two groups, according to their side chain structures, as nitrogen-containing BPs (NBPs) and non-nitrogen-containing BPs (non-NBPs).
Keiko Suzuki, Sadaaki Takeyama, Shinobu Murakami, Masahiro Nagaoka, Mirei Chiba, Kaoru Igarashi, Hisashi Shinoda   +6 more
doaj   +1 more source

A bisphosphonate for F-19-magnetic resonance imaging [PDF]

, 2016
19F-magnetic resonance imaging (MRI) is a promising technique that may allow us to measure the concentration of exogenous fluorinated imaging probes quantitatively in vivo.
Botnar, RM, De Rosales, RTM, Kenny, GD, Shaw, KP, Sivachelvam, S, White, AJP   +5 more
core   +1 more source

Targeting the Hyperglycemic Pre‐Metastatic Niche to Prevent Breast Cancer Bone Metastasis: Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
Abstract The recent pioneering study by Ye et al. (Adv Sci. 2025;12(37):e0504924) provides compelling evidence that systemic hyperglycemia orchestrates a pre‐metastatic niche (PMN) in bone, promoting breast cancer metastasis and identifying Receptor for Advanced Glycation End‐products (RAGE) inhibition as a viable therapeutic strategy.
DuJiang Yang, Jiexiang Yang, GuoYou Wang
wiley   +1 more source

Preparation, Characterization, and Radiolabeling of [⁶⁸Ga]Ga-NODAGA-Pamidronic Acid: A Potential PET Bone Imaging Agent

Molecules, 2020
Early diagnosis of bone metastases is crucial to prevent skeletal-related events, and for that, the non-invasive techniques to diagnose bone metastases that make use of image-guided radiopharmaceuticals are being employed as an alternative to traditional
Zarif Ashhar, Nor Azah Yusof, Fathinul Fikri Ahmad Saad, Siti Mariam Mohd Nor, Faruq Mohammad, Wan Hamirul Bahrin Wan Kamal, Muhammad Hishar Hassan, Hazlina Ahmad Hassali, Hamad A. Al-Lohedan   +8 more
doaj   +1 more source

Reduced mortality and subsequent fracture risk associated with oral bisphosphonate recommendation in a fracture liaison service setting: A prospective cohort study [PDF]

, 2018
Objective: Osteoporotic fragility fractures, that are common in men and women, signal increased risk of future fractures and of premature mortality. Less than one-third of postmenopausal women and fewer men are prescribed active treatments to reduce ...
Bliuc, Dana, Center, Jacqueline R, Dinant, Geert-Jan, Eisman, John A, Geusens, Piet P, McLellan, Alastair R, Tran, Thach, van den Bergh, Joop P, van Geel, Tineke A   +8 more
core   +4 more sources

Clinical Presentation of the Longest Reported Living Individual With Bent Bone Dysplasia—FGFR2‐Related

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The FGFR2 gene, encoding the FGFR2 protein, plays a crucial role in embryonic cell development, particularly in bone tissue. Bent Bone Dysplasia (BBD), FGFR2‐related (MIM# 614592), is a rare severe skeletal dysplasia characterized by craniofacial differences, reduced bone mineral density, and bowed long bones.
Cheyenne Bates, Pardeep Gill, Matthew Choi, Frances Mahon, Blake Yarascavitch, Audrey Lim, Resham Ejaz   +6 more
wiley   +1 more source

Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs

Molecules, 2020
Neglected tropical diseases such as Chagas disease and leishmaniasis affect millions of people around the world. Both diseases affect various parts of the globe and drugs traditionally used in therapy against these diseases have limitations, especially ...
Joice Castelo Branco Santos, Jonathas Alves de Melo, Sweta Maheshwari, Wendy Marina Toscano Queiroz de Medeiros, Johny Wysllas de Freitas Oliveira, Cláudia Jassica Moreno, L. Mario Amzel, Sandra B. Gabelli, Marcelo Sousa Silva   +8 more
doaj   +1 more source