Results 51 to 60 of about 505,943 (359)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Relações planta-animal em ambiente pastoril heterogêneo: padrões de deslocamento e uso de estações alimentares Plant-animal relationships in a heterogeneous pastoral environment: displacement patterns and feeding station use

Revista Brasileira de Zootecnia, 2009
Avaliou-se como o padrão de deslocamento e de utilização de estações alimentares podem ser afetados por alturas de manejo de 4, 8, 12 e 16 cm numa pastagem nativa.
Edna Nunes Gonçalves, Paulo César de Faccio Carvalho, Thais Devincenzi, Marília Lazzarotto Terra Lopes, Fabiana Kellermann de Freitas, Aino Victor Ávila Jacques   +5 more
doaj   +1 more source

Eosinophilic dermatosis of hematologic malignancy: a case report [PDF]

, 2020
Eosinophilic dermatosis of hematologic malignancy (EDHM) is a dermatosis characterized by tissue eosinophilia that has been previously reported as insect bite-like reaction.
Almeida, FT, Brito, C, Caldas, R, Ferreira, O, Rodrigues, AP   +4 more
core  

The risk of rabies spread in Japan: a mathematical modeling assessment [PDF]

, 2018
Rabies was eliminated from Japan in 1957. In the 60 years since elimination, vaccination coverage has declined and dog ownership habits have changed. The purpose of this study was to assess the current risk of rabies spread in Japan. A spatially explicit
Hampson, K., Kadowaki, H., Makita, K., Tojinbara, K., Yamada, A.   +4 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Questionnaire Background on the Hognose Snake (Heterodon nasicus) Breeders’ Awareness of the Risk of Being Bitten

Animals, 2021
Several cases of Heterodon nasicus bites producing various symptoms have already been described. In this paper, a survey was conducted among Polish breeders of this species, where 47.7% of the respondents admitted that their snakes had tried to bite them,
Damian Zieliński
doaj   +1 more source

Can Masticatory Electromyography be Normalised to Submaximal Bite Force? [PDF]

, 2015
The combination of bite force and jaw muscle electromyography (EMG) provides an insight into the performance of the stomatognathic system, especially in relation to dynamic movement tasks.
Bakke, Burden, Burdette, Burnett, Burnett, Castroflorio, Ferrario, Ferrario, Gomes, Hara, Healey, Hertel, Hosman, Kemsley, Knutson, Koc, Minshull, Paphangkorakit, Rues, Saifuddin, Siéssere, Suvinen, Tecco, Weir, Worrell   +24 more
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Breastfeeding and non-nutritive sucking patterns related to the prevalence of anterior open bite in primary dentition [PDF]

, 2011
OBJECTIVE: Nutritional, immunological and psychological benefts of exclusive breastfeeding for the frst 6 months of life are unequivocally recognized. However, mothers should also be aware of the importance of breastfeeding for promoting adequate oral ...
COTRIM-FERREIRA, Flávio Augusto, FERREIRA, Rívea Inês, GARIB, Daniela Gamba, ROMERO, Camila Campos, SCAVONE-JUNIOR, Helio   +4 more
core   +4 more sources

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source