Results 121 to 130 of about 2,684 (148)

Ultrasound findings of BK polyomavirus-associated nephropathy in renal transplant patients

Journal of Nephrology, 2016
BK polyomavirus (BKV) is an emerging pathogen in immunocompromised patients. BKV infection occurs in 1-9 % of renal transplants and causes chronic nephropathy or graft loss. Diagnosis of BKV-associated nephropathy (BKVAN) is based on detection of viruria then viremia and at least a tubule-interstitial nephritis at renal biopsy. This paper describes the
Mauro Dugo, Margherita Mangino, Mario Meola, Ilaria Petrucci, Maria Luisa Valente, Licia Laurino, Mario Stella, Stefania Mastrosimone, Anna Brunello, Bice Virgilio, Monica Rizzolo, Maria Cristina Maresca   +11 more
openaire   +3 more sources

BK Polyomavirus‐associated nephropathy managed by screening policy in a real‐life setting

Transplant Infectious Disease, 2019
AbstractBackgroundBK polyomavirus‐associated nephropathy (PyVAN) is an important complication after kidney transplantation. Prevalence ranges from 1% to 10%, and graft loss occurs in approximately 50% of the cases. There is no effective treatment, so early viral detection with immunosuppression tapering is the current strategy to prevent PyVAN.AimsTo ...
Fernanda Vianna Vacilotto Raupp, Gisele Meinerz, Cynthia Keitel da Silva, Patrícia Campos d’Almeida Bianco, João Carlos Goldani, Karla Lais Pegas, Josiane Borges Stolfo, Valter Duro Garcia, Elizete Keitel   +8 more
openaire   +2 more sources

Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients – A systematic review

Transplantation Reviews, 2020
BK polyomavirus (BKPyV) associated nephropathy (BKVAN) is seen in about 5% of renal transplant patients and can lead to chronic graft failure or graft loss. No effective therapy is available. Leflunomide has shown promising results in BKVAN. We performed a systematic review about the use of leflunomide for the treatment of BKVAN. The recommendations of
Laila, Schneidewind, Thomas, Neumann, Desiree L, Dräger, Jennifer, Kranz, Oliver W, Hakenberg   +4 more
openaire   +2 more sources

BK virus infection activates the TNFα/TNF receptor system in Polyomavirus-associated nephropathy

Molecular and Cellular Biochemistry, 2015
Polyomavirus-associated nephropathy due to BK virus infection (BKVAN) is recognized as an important cause of significant kidney transplant dysfunction often leading to renal graft loss. The activation of innate immune defense mechanisms during BKVAN is still poorly understood and an altered regulation of inflammatory mediators by resident kidney cells ...
Andrea, Ribeiro, Monika, Merkle, Nasim, Motamedi, Hans, Nitschko, Simone, Köppel, Markus, Wörnle   +5 more
openaire   +2 more sources

Concurrent cytomegalovirus glomerulitis and BK polyomavirus‐associated nephropathy in a kidney allograft biopsy

Transplant Infectious Disease, 2016
AbstractA 58‐year‐old renal transplant recipient underwent biopsy 11 weeks post transplantation for increasing creatinine. The biopsy showed cytomegalovirus (CMV) glomerulitis together with BK polyomavirus (BKPyV)‐associated nephropathy (PVAN). Treatment with intravenous ganciclovir and overall reduction in maintenance immunosuppression resulted in ...
I O, Chikeka, A, Paulk, A, Haririan, J C, Papadimitriou, C B, Drachenberg   +4 more
openaire   +2 more sources

Evaluation of a Preemptive Strategy for BK Polyomavirus-Associated Nephropathy Based on Prospective Monitoring of BK Viremia: A Kidney Transplantation Center Experience

Transplantation Proceedings, 2010
BK polyomavirus-associated nephropathy (BKPVAN) is a major cause of renal failure early after kidney transplantation. The present study reports the preliminary results of prospective monitoring including a preemptive strategy for BKPVAN during the first year after kidney transplantation.We monitored BK virus DNA in blood at months 1, 2, 3, 6, 9, and 12
E, Renoult, F, Coutlée, M, Pâquet, G, St Louis, C, Girardin, M-C, Fortin, H, Cardinal, R, Lévesque, W, Schürch, M, Latour, A, Barama, M-J, Hébert   +11 more
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Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study

Transplant Infectious Disease, 2019
AbstractBackgroundBK polyomavirus associated nephropathy (BKPyVAN) is a significant clinical issue in kidney transplant (KT) recipients. No specific therapy is currently available, although treatment with leflunomide may be part of the therapeutic strategy. Here, we sought to examine the impact of leflunomide on the evolution of BKPyVAN.MethodsThis was
Keller, Nicolas, Duquennoy, Simon, Fafi-Kremer, Samira, Morelon, Emmanuel, Bouvier, Nicolas, Moulin, Bruno, Hurault de Ligny, Bruno, Caillard-Ohlmann, Sophie, Conrad, Anne   +8 more
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Predictive Value of the Combination of Peripheral Blood Lymphocyte Count and Urinary Cytology in BK Polyomavirus–associated Nephropathy

Transplantation Proceedings, 2019
Graft biopsy is the gold standard for diagnosis of BK polyomavirus-associated nephropathy (BKPyVAN), and polymerase chain reaction is the most specific screening technique. Development of a noninvasive, cost-effective marker for BKPyVAN is important.We reviewed 492 adult kidney transplant patients.
Kosuke, Masutani, Akihiro, Tsuchimoto, Yuta, Matsukuma, Shigeru, Tanaka, Keizo, Kaku, Hiroshi, Noguchi, Kei, Kurihara, Yasuhiro, Okabe, Toshiaki, Nakano, Kazuhiko, Tsuruya, Hitoshi, Nakashima, Masafumi, Nakamura, Takanari, Kitazono   +12 more
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BK Polyomavirus Associated Nephropathy in a Native Kidney

2022
Gupta, Nikhil, Ripudaman Munjal
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#1951 Prediction of BK Polyomavirus associated nephropathy by the NEPHROVIR method in kidney transplant recipients with BK Polyomavirus-DNAemia

Nephrology Dialysis Transplantation
Abstract Background and Aims BK Polyomavirus (BKPyV) remains a significant complication after kidney transplantation. Due to BKPyV intra-graft replication, biopsy-proven BKPyV-associated nephropathy (BKPyVAN) affects nearly 10% of patients and causes graft loss in more than 50% of cases ...
Manon Dekeyser, Marie-Ghislaine de Goër de Herve, Houria Hendel-Chavez, Karen Bargiel, Florence Herr, Yassine Taoufik, Antoine Durrbach   +6 more
openaire   +1 more source