Results 101 to 110 of about 3,946 (192)

A Phase I Study Evaluating Safety and Tolerability of Viral‐Specific T Cells Against BK‐Virus in Adult Kidney Transplant Recipients

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT BK polyomavirus (BKPyV) poses a significant threat to kidney transplant recipients (KTR). Current management primarily involves reducing immunosuppression, which increases the risk of rejection. Cell‐based immunotherapy with virus‐specific T cells (VST) has emerged as an alternative approach for treating BKPyV in KTRs. This single‐center phase
Lucy Ptak, Ross O. Meyers, Olga Radko‐Ganz, Kimberly A. McDowell, Margaret Jorgenson, Maggie Chilsen, Didier Mandelbrot, Jacques Galipeau, Sandesh Parajuli   +8 more
wiley   +1 more source

Renal transplant pathology: main morphological findings and how to sign out biopsies [PDF]

, 2008
Renal transplant has reached remarkable and growing rates of success since its introduction; nowadays it is a widely used replacement therapy. Renal allograft biopsies are increasingly more frequent in the routine of pathology laboratories, whose ...
Araújo, Sérgio, Caldas, Maria Lúcia, David, Daisa Ribeiro, Edelweiss, Maria Isabel Albano, Franco, Marcello Fabiano de, Malheiros, Denise, Pegas, Karla Laís, Sementilli, Angelo, Soares, Maria Fernanda Sanches, Visona, Iria   +9 more
core   +2 more sources

Transferrin Saturation Can Serve as a Novel Biomarker for Predicting the Occurrence and Development of BK Virus‐Related Nephropathy After Kidney Transplantation

Journal of Medical Virology, Volume 97, Issue 3, March 2025.
ABSTRACT BK polyomavirus reactivation is a common complication after kidney transplantation, affecting the long‐term survival of the transplanted kidney. However, it is unclear whether iron levels affect BKPyV reactivation after kidney transplantation.
Yongchuang Yan, Zhigang Wang, Yonghua Feng, Yang Qiu, Yuanbo Qi, Fumin Cheng, Yi Feng, Di Zhang, Guiwen Feng, Wenjun Shang   +9 more
wiley   +1 more source

Renal Transplantation in HIV-Infected Patients: The First Portuguese Review [PDF]

, 2015
INTRODUCTION: With the introduction of combination antiretroviral therapy (cART), prognosis of human immunodeficiency virus (HIV) infection has been improved and kidney transplantation (KT) in HIV-positive patients became possible.
Cruz, P, Machado, D, Nolasco, F, Nunes, A, Oliveira, C, Querido, S, Sampaio, S, Silva, C, Weigert, A   +8 more
core   +1 more source

Tumor Necrosis Factor‐Alpha Inhibits the Replication of Patient‐Derived Archetype BK Polyomavirus While Activating Rearranged Strains

Journal of Medical Virology, Volume 97, Issue 2, February 2025.
ABSTRACT To date, no drugs are approved for BK polyomavirus (BKPyV) reactivation, a major cause of nephropathy after kidney transplantation. Recently, tumor necrosis factor‐α (TNF‐α) blockade has been proposed as a promising therapy, however, the effect of TNF‐α on the clinically most common archetype (ww) BKPyV remained unclear.
Lise Lauterbach‐Rivière, Lucia Thuringer, Pascal Feld, Lina Kathrin Toews, Jessica Schüssler, Jonas Klinz, Lars Gläser, Stefan Lohse, Anna Sternjakob, Gilles Gasparoni, Kathrin Kattler‐Lackes, Jörn Walter, Marcel A. Lauterbach, Sven Rahmann, Lars Möller, Michael Laue, Martin Janssen, Michael Stöckle, David Schmit, Danilo Fliser, Sigrun Smola   +20 more
wiley   +1 more source

Immunity to Polyomavirus BK Infection: Immune Monitoring to Regulate the Balance between Risk of BKV Nephropathy and Induction of Alloimmunity

Clinical and Developmental Immunology, 2013
Polyomavirus BK-associated nephropathy (PyVAN) is the main infectious cause of allograft damage after kidney transplantation. A number of studies revealed an association between the presence of BKV-specific cellular immunity and BK viral clearance, with ...
Patrizia Comoli, Michela Cioni, Sabrina Basso, Chiara Gagliardone, Leonardo Potenza, Enrico Verrina, Mario Luppi, Marco Zecca, Gian Marco Ghiggeri, Fabrizio Ginevri   +9 more
doaj   +1 more source

Polyoma BK virus: an emerging opportunistic infectious agent of the human central nervous system

Brazilian Journal of Infectious Diseases, 2011
BK virus, a double-stranded DNA virus, is a member of the Polyomaviridae family which is known to infect humans. Clinical evidence of disease is mostly encountered in immunosuppressed individuals such as AIDS patients or those who undergo renal or bone ...
Rodrigo Lopes da Silva, M.D.
doaj   +1 more source

Kidney transplantation in children [PDF]

, 2014
Transplantation in children with kidney failure once presented many technical, immunologic, and logistic problems that led to worse patient and allograft survival, as compared with adults.
Dharnidharka, Vikas R, Fiorina, Paolo, Harmon, William E   +2 more
core   +2 more sources

Polyomavirus – an emergent pathogen in transplant recipients [PDF]

Einstein (São Paulo), 2007
Medical centers that work with transplants often face opportunisticinfections that demand specific tools to make diagnosis. Theprevalence of latent polyomavirus infections is high, and the mostcommon site of latency of the most prevalent polyomavirus in ...
Juliana de Moura Montagner, Tatiana Ferreira Michelon, Regina Barbosa Schroeder, Bárbara Tengaten Fontanelle, Alexandre Tavares Duarte de Oliveira, Janaina Gomes da Silveira, Márcia Silveira Graudenz, Cláudio Osmar Pereira Alexandre, Jorge Neumann   +8 more
doaj  

A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring. [PDF]

, 2019
A Common Rejection Module (CRM) consisting of 11 genes expressed in allograft biopsies was previously reported to serve as a biomarker for acute rejection (AR), correlate with the extent of graft injury, and predict future allograft damage.
Bestard, Oriol, Damm, Izabella, Geraedts, Anna CM, Hsieh, Szu-Chuan, Liberto, Juliane M, Sarwal, Minnie M, Schroeder, Andrew, Sigdel, Tara K, Yang, Joshua YC   +8 more
core   +2 more sources