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BK Polyomavirus-Induced Nephropathy in Native Kidney
Cureus, 2023 BK polyomavirus has been well-studied as an opportunistic infection in immunocompromised kidney transplant patients. In the majority of the population, BK polyomavirus establishes a lifelong infection in renal tubular and uroepithelial cells; however, in an immunocompromised state, the virus can reactivate and can lead to BK polyomavirus-associated ...
Munjal, Ripudaman S +3 more
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Kaohsiung Journal of Medical Sciences, 2016 Previous studies regarding the prevention of BK viremia following renal transplantation with fluoroquinolone have yielded conflicting results. The purpose of this systematic review was to examine the evidence regarding the efficacy of fluoroquinolone in ...
Tu-Run Song +6 more
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BK polyomavirus—pathogen, paradigm and puzzle
Nephrology Dialysis Transplantation, 2019 AbstractBK virus is a polyomavirus with seroprevalence rates of 80% in adults. Infection is usually acquired during childhood, and the virus is benign or pathologic depending on immune status. The virus reactivates in immunodeficiency states, mostly among transplant (either kidney or bone marrow) recipients.
Suman Krishna Kotla +3 more
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BK polyomavirus: latency, reactivation, diseases and tumorigenesis
Frontiers in Cellular and Infection Microbiology, 2023 The identification of the first human polyomavirus BK (BKV) has been over half century, The previous epidemiological and phylogenetic studies suggest that BKV prevailed and co-evolved with humans, leading to high seroprevalence all over the world. In general, BKV stays latent and symptomless reactivation in healthy individuals.
Xianfeng Zhou +4 more
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A Cell Culture Model of BK Polyomavirus Persistence, Genome Recombination, and Reactivation
mBio, 2021 BK polyomavirus (BKPyV) generally establishes a persistent subclinical infection in healthy individuals but can cause severe disease in transplant recipients.
Linbo Zhao, Michael J. Imperiale
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Molecular Evaluation of BK Polyomavirus Nephropathy
American Journal of Transplantation, 2005 Understanding at a molecular level, the immunologic response of polyomavirus nephropathy (PVN), a critical cause of kidney graft loss, could lead to new targets for treatment and diagnosis. We undertook a transcriptional evaluation of kidney allograft biopsies from recipients with PVN or acute rejection (AR), as well as from recipients with stable ...
R B, Mannon +9 more
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Indian Journal of Transplantation, 2022 Purpose: Hemorrhagic cystitis (HC) which occurs in 9%–31% of recipients after hematopoietic stem cell transplantation (HSCT) is an important cause of morbidity and mortality.
Ayça Koca Yozgat +7 more
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BK Virus in Cancer Development
Current Issues in Pharmacy and Medical Sciences, 2018 Polyomavirus (PyV) was discovered by accident in 1950 in the course of describing an infectious factor causing multiple tumours in rodents. The term is derived from two Greek words: poly (many) and oma (tumour).
Pasternak Justyna +2 more
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Detection of Bk Polyomavirus Antigen in Patients with Acute Lymphoblastic Leukemia
Diyala Journal of Medicine, 2023 Background: BK polyomavirus that is acquired in early childhood as BKPyV is near ubiquitous in adults with a seroprevalence of >80%, it has been found as the main cause of hemorrhagic cystitis in hematopoietic stem cell transplantation patients, due to
Safa H Ali , +3 more
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Taking the Scenic Route: Polyomaviruses Utilize Multiple Pathways to Reach the Same Destination
Viruses, 2020 Members of the Polyomaviridae family differ in their host range, pathogenesis, and disease severity. To date, some of the most studied polyomaviruses include human JC, BK, and Merkel cell polyomavirus and non-human subspecies murine and simian virus 40 ...
Colleen L. Mayberry, Melissa S. Maginnis
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