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BK polyomavirus-associated nephropathy [PDF]

open access: yesChildhood Kidney Diseases, 2022
BK polyomavirus (BKPyV) is a ubiquitous virus residing in the kidney tubules and is clinically significant only in immunocompromised patients. In clinical practice, BKPyV is a causative pathogen of BKPyV associated nephropathy (BKVAN) in kidney allograft recipients or hemorrhagic cystitis of hematopoietic stem cell transplant recipients.
Yo Han Ahn, Hee Gyung Kang
doaj   +3 more sources

BK Polyomavirus—Biology, Genomic Variation and Diagnosis [PDF]

open access: yesViruses, 2021
The BK polyomavirus (BKPyV), a representative of the family Polyomaviridae, is widespread in the human population. While the virus does not cause significant clinical symptoms in immunocompetent individuals, it is activated in cases of immune deficiency, both pharmacological and pathological.
Jacek Furmaga   +2 more
exaly   +5 more sources

Exploring the mechanism of BK polyomavirus-associated nephropathy through consensus gene network approach.

open access: yesPLoS ONE, 2023
BK polyomavirus-associated nephropathy occurs in kidney transplant recipients under immunosuppressive treatment. BK polyomavirus is implicated in cancer development and invasion, and case reports of renal cell carcinoma and urothelial carcinoma possibly ...
Noriaki Sato   +8 more
doaj   +2 more sources

BK polyomavirus: emerging pathogen [PDF]

open access: yesMicrobes and Infection, 2012
BK polyomavirus (BKPyV) is a small double-stranded DNA virus that is an emerging pathogen in immunocompromised individuals. BKPyV is widespread in the general population, but primarily causes disease when immune suppression leads to reactivation of latent virus.
Michael J Imperiale
exaly   +3 more sources

BK Polyomavirus in Renal Transplantation: Virological Notes for Monitoring and Diagnosis. [PDF]

open access: yesBiomolecules
Polyomavirus-associated nephropathy was first reported over 50 years ago. However, it still represents a cause of renal injury in kidney transplant recipients, particularly in the first two years post-transplantation, with occurrence rates of 1–10%.
Costa C, Sidoti F, Bondi A, Curtoni A.
europepmc   +2 more sources

BK polyomavirus nephropathy in two kidney transplant patients with distinct diagnostic strategies for BK virus and similar clinical outcomes: two case reports

open access: yesJournal of Medical Case Reports, 2017
Background BK polyomavirus-associated nephropathy is an important cause of post-transplantation renal failure. We present two cases of BK polyomavirus-associated nephropathy who were submitted to contrasting strategies of clinical follow-up to BK ...
Ana Luisa Figueira Gouvêa   +10 more
doaj   +2 more sources

Native BK Polyomavirus Nephropathy in an Orthotopic Heart Transplant Patient

open access: yesJournal of Investigative Medicine High Impact Case Reports, 2023
BK polyomavirus nephropathy (BKVN) is a common cause of nephropathy in kidney transplant patients and is typically seen within the first year after transplantation.
Zachary M. Thompson MD   +5 more
doaj   +2 more sources

BK Polyomavirus and Transformation [PDF]

open access: yesAmerican Journal of Transplantation, 2011
The human BK polyomavirus (PyV) (BKV) was isolated from the urine of a kidney transplant patient with the initials B.K. after cells with nuclear atypia were noted in the urine in the diagnostic workup of an alloureter stenosis. Electron microscopy revealed intranuclear inclusions of nonenveloped viral particles of 40–45-nm diameter suggesting infection
Tina Dalianis, Hans H. Hirsch
core   +6 more sources

BK Polyomavirus in Solid Organ Transplantation [PDF]

open access: yesAmerican Journal of Transplantation, 2013
The human BK polyomavirus (BKV) is the major cause of polyomavirus-associated nephropathy (PyVAN) putting 1-15% of kidney transplant patients at risk of premature allograft failure, but is less common in other solid organ transplants. Because effective antiviral therapies are lacking, screening kidney transplant patients for BKV replication in urine ...
Hirsch, H. H., Randhawa, P.
openaire   +5 more sources

A highly potent human antibody neutralizing all serotypes of BK polyomavirus. [PDF]

open access: yesPLoS Pathog
BK polyomavirus infection poses a significant risk to kidney transplant recipients. Reactivation of dormant virus in the transplanted kidney, triggered by immunosuppression, can lead to BK polyomavirus-associated nephropathy in up to 10% of transplants ...
Weber M   +12 more
europepmc   +2 more sources

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