Results 101 to 110 of about 61,588 (194)

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Polyomaviruses BK and JC DNA infection in peripheral blood cells from blood donors

Brazilian Journal of Infectious Diseases, 2019
Objectives: To investigate the prevalence of human polyomavirus (BK and JC viruses) infection in peripheral blood mononuclear cells of healthy blood donors. Methods: The study included 250 healthy blood donors.
Malihe Fathi Haghighi, Noorossadat Seyyedi, Ali Farhadi, Farahnaz Zare, Leila Kasraian, Gholam Reza Refiei Dehbidi, Reza Ranjbaran, Abbas Behzad-Behbahani   +7 more
doaj   +1 more source

Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection

Viruses, 2020
Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating ...
Paul Clark, Gretchen V. Gee, Brandon S. Albright, Benedetta Assetta, Ying Han, Walter J. Atwood, Daniel DiMaio   +6 more
doaj   +1 more source

Late BK Nephropathy 15 years post kidney transplant following chemotherapy: A case report

IDCases
BK Polyomavirus (BKPyV) is an important risk factor for premature graft loss following kidney transplant. Current practice guidelines recommend screening for BK virus DNA for 2 years after kidney transplant as the risk of BK Polyomavirus associated ...
Anum Hamiduzzaman, Jean Hou, Tram Higgins, Pryce Gaynor, Abhirami Shankar, Erik L. Lum   +5 more
doaj   +1 more source

A Retrograde Trafficking Inhibitor of Ricin and Shiga-Like Toxins Inhibits Infection of Cells by Human and Monkey Polyomaviruses

mBio, 2013
Polyomaviruses are ubiquitous pathogens that cause severe disease in immunocompromised individuals. JC polyomavirus (JCPyV) is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML), whereas BK ...
Christian D. S. Nelson, Dan W. Carney, Aaron Derdowski, Alex Lipovsky, Gretchen V. Gee, Bethany O’Hara, Paul Williard, Daniel DiMaio, Jason K. Sello, Walter J. Atwood   +9 more
doaj   +1 more source

BK polyomavirus infection: more than 50 years and still a threat to kidney transplant recipients

Frontiers in Transplantation
BK polyomavirus (BKPyV) is a ubiquitous human polyomavirus and a major infection after kidney transplantation, primarily due to immunosuppression. BKPyV reactivation can manifest as viruria in 30%–40%, viremia in 10%–20%, and BK polyomavirus-associated ...
Sandesh Parajuli, Fahad Aziz, Weixiong Zhong, Arjang Djamali   +3 more
doaj   +1 more source

An unusually high substitution rate in transplant-associated BK polyomavirus in vivo is further concentrated in HLA-C-bound viral peptides.

PLoS Pathogens, 2018
Infection with human BK polyomavirus, a small double-stranded DNA virus, potentially results in severe complications in immunocompromised patients. Here, we describe the in vivo variability and evolution of the BK polyomavirus by deep sequencing.
Pilar Domingo-Calap, Benjamin Schubert, Mélanie Joly, Morgane Solis, Meiggie Untrau, Raphael Carapito, Philippe Georgel, Sophie Caillard, Samira Fafi-Kremer, Nicodème Paul, Oliver Kohlbacher, Fernando González-Candelas, Seiamak Bahram   +12 more
doaj   +1 more source

Polyomavirus specific cellular immunity: from BK-virus-specific cellular immunity to BK-virus-associated nephropathy ?

Frontiers in Immunology, 2015
In renal transplantation, BK-virus-associated nephropathy has emerged as a major complication, with a prevalence of 5–10% and graft loss in >50% of cases. BK-virus is a member of the Polyomavirus family and rarely induces apparent clinical disease in the
manon edekeyser, helene efrancois, severine ebeaudreuil, Antoine eDurrbach   +3 more
doaj   +1 more source

The natural history of BK polyomavirus and the host immune response after stem cell transplantation.

Clinical Infectious Diseases, 2019
BACKGROUND BK polyomavirus (BKPyV) is associated with symptomatic hemorrhagic cystitis after hematopoietic cell transplantation (HCT). Little is known about the host immune response, effectiveness of antiviral treatment, or impact of asymptomatic ...
B. Laskin, M. Denburg, S. Furth, Taylor Moatz, M. Altrich, S. Kleiboeker, C. Lutzko, Xiang Zhu, J. Blackard, S. Jodele, A. Lane, G. Wallace, C. Dandoy, K. Lake, Alexandra Duell, Bridget Litts, A. Seif, T. Olson, N. Bunin, S. Davies   +19 more
semanticscholar   +1 more source

Posoleucel for BK Polyomavirus in Kidney Transplant Recipients.

J Am Soc Nephrol
Wilhelm M, Geng A, Schaub S, Hirsch HH.
europepmc   +3 more sources