Results 41 to 50 of about 68,161 (247)

The Expression of Inflammatory Mediators in Bladder Pain Syndrome [PDF]

European Urology, 2016
Bladder pain syndrome (BPS) pathology is poorly understood. Treatment strategies are empirical, with limited efficacy, and affected patients have diminished quality of life.We examined the hypothesis that inflammatory mediators within the bladder contribute to BPS pathology.Fifteen women with BPS and 15 women with stress urinary incontinence without ...
Offiah, Ifeoma, Didangelos, Athanasios, Dawes, John, Cartwright, Rufus, Khullar, Vik, Bradbury, Elizabeth J., O'Sullivan, Suzanne, Williams, Dic, Chessell, Iain P., Pallas, Kenny, Graham, Gerry, O’Reilly, Barry A., McMahon, Stephen B.   +12 more
openaire   +6 more sources

Circulating sex steroids and bladder pain sensitivity in dysmenorrhea

Molecular Pain, 2021
Although elevated estradiol levels facilitate chronic pelvic pain in animal models, it remains to be determined whether sex steroid levels are altered in a cross-section of women with chronic pelvic pain (CPP) and those at-risk for developing CPP.
Kevin M Hellman, Folabomi A Oladosu, Ellen F Garrison, Genevieve E Roth, Katlyn E Dillane, Frank F Tu   +5 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

Summary of the 2023 report of the international consultation on incontinence interstitial cystitis/bladder pain syndrome (IC/BPS) committee

Continence, 2023
Interstitial cystitis and bladder pain syndrome are essentially interchangeable as there is no accepted definition that clearly delineates the interstitial cystitis syndrome from bladder pain syndrome.
Philip Hanno, Mauro Cervigni, Myung Soo Choo, J. Quentin Clemens, Ming-Huei Lee, Sachin Malde, Jane Meijlink, Michael Samarinas, Tomohiro Ueda, Daniela Gold   +9 more
doaj   +1 more source

Survival Outcomes in Older Adults with Axial Spondyloarthritis and Concomitant Cancer

Arthritis Care &Research, Accepted Article.
Objective The objective of this study was to determine survival outcomes in older adults with axial spondyloarthritis (axSpA) and concomitant cancer. Methods We conducted a population‐based study using Medicare claims data linked to Surveillance, Epidemiology, and End Results data to determine overall survival (OS) and cancer‐specific survival (CSS) in
Savannah Bowman, Mei Li, Xiudong Lei, Hui Zhao, Juan I. Ruiz, Sharon H. Giordano, Alexis R. Ogdie, Maria E. Suarez‐Almazor   +7 more
wiley   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Bladder Pain Syndrome With Repeated Bladder Hydrodistention—A Case of Functional Somatic Syndrome Considered in Relation to Alexithymia

IJU Case Reports
Introduction We present a patient with bladder pain syndrome (BPS) who underwent repeated bladder hydrodistentions. Case Presentation A female patient visited our department because of refractory bladder pain.
Naoki Wada, Tsubasa Hatakeyama, Taichiro Ishimaru, Ryoken Tsunekawa, Kotona Miyauchi, Daiki Kikuchi, Takeya Kitta, Masaki Watanabe   +7 more
doaj   +1 more source

Functional brain imaging and central control of the bladder in health and disease

Frontiers in Physiology, 2022
Central control of the bladder is a complex process. With the development of functional imaging technology and analysis methods, research on brain-bladder control has become more in-depth.
Dongqing Pang, Dongqing Pang, Dongqing Pang, Yi Gao, Yi Gao, Yi Gao, Limin Liao, Limin Liao, Limin Liao   +8 more
doaj   +1 more source

ADNP‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman, Ana Kolevzon, Paige Siper, Tess Levy, Jeffrey M. Saland, Yitzchak Frank, Robert Rapaport, Kayla Kupietzky, William E. Bennett Jr, Bruce Gelb, Sandra Bedrosian Sermone, Alexander Kolevzon   +11 more
wiley   +1 more source