Results 41 to 50 of about 345,336 (269)

Differential Neuroendocrine Responses and Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis Following Repeated Mild Concussive Impacts and Blast Exposures in a Rat Model

Brain Sciences
Traumatic brain injury (TBI) remains a significant public health concern, particularly among military personnel and contact sport athletes who are frequently exposed to repeated blast overpressure waves and mild concussive impacts, respectively.
Rex Jeya Rajkumar Samdavid Thanapaul, Jishnu K. S. Krishnan, Manoj Y. Govindarajulu, Chetan Y. Pundkar, Gaurav Phuyal, Joseph B. Long, Peethambaran Arun   +6 more
doaj   +1 more source

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Repeated Low-Level Blast Overpressure Leads to Endovascular Disruption and Alterations in TDP-43 and Piezo2 in a Rat Model of Blast TBI

Frontiers in Neurology, 2019
Recent evidence linking repeated low-level blast overpressure exposure in operational and training environments with neurocognitive decline, neuroinflammation, and neurodegenerative processes has prompted concern over the cumulative deleterious effects ...
Lanier Heyburn, Rania Abutarboush, Rania Abutarboush, Samantha Goodrich, Samantha Goodrich, Rodrigo Urioste, Andrew Batuure, Jonathan Statz, Jonathan Statz, Donna Wilder, Stephen T. Ahlers, Joseph B. Long, Venkata Siva Sai Sujith Sajja   +12 more
doaj   +1 more source

Role of Interfacial Conditions on Blast Overpressure Propagation Into the Brain

Frontiers in Neurology, 2020
The complex interfacial condition between the human brain and the skull has been difficult to emulate in a surrogate system. Surrogate head models have typically been built using a homogeneous viscoelastic material to represent the brain, but the effect ...
YungChia Chen, Thomas J. O'Shaughnessy, Gary H. Kamimori, David M. Horner, Michael J. Egnoto, Amit Bagchi   +5 more
doaj   +1 more source

Non-linear Dynamic Analysis of Steel Hollow I-core Sandwich Panel under Air Blast Loading [PDF]

Civil Engineering Infrastructures Journal, 2015
In this paper, the non-linear dynamic response of novel steel sandwich panel with hollow I-core subjected to blast loading was studied. Special emphasis is placed on the evaluation of midpoint displacements and energy dissipation of the models.
Asghar Vatani Oskouei, Foad Kiakojouri
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Localizing Clinical Patterns of Blast Traumatic Brain Injury Through Computational Modeling and Simulation

Frontiers in Neurology, 2021
Blast traumatic brain injury is ubiquitous in modern military conflict with significant morbidity and mortality. Yet the mechanism by which blast overpressure waves cause specific intracranial injury in humans remains unclear.
Scott T. Miller, Candice F. Cooper, Paul Elsbernd, Joseph Kerwin, Ricardo Mejia-Alvarez, Adam M. Willis, Adam M. Willis   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Blast Overpressure-Induced Neuroinflammation and Axonal Injury in the Spinal Cord of Ferrets

Brain Sciences
Background: Blast-induced spinal cord injuries (bSCI) account for 75% of all combat-related spinal trauma and are associated with long-term functional impairments.
Gaurav Phuyal, Chetan Y. Pundkar, Manoj Y. Govindarajulu, Rex Jeya Rajkumar Samdavid Thanapaul, Aymen Al-Lami, Ashwathi Menon, Joseph B. Long, Peethambaran Arun   +7 more
doaj   +1 more source