Results 61 to 70 of about 345,336 (269)

BLAST: THE REDSHIFT SURVEY [PDF]

The Astrophysical Journal, 2009
Accepted for publication in the Astrophysical Journal. Maps and associated results are available at http://blastexperiment.info/
Eales, Stephen, Chapin, Edward L., Devlin, Mark J., Dye, Simon, Halpern, Mark, Hughes, David H., Marsden, Gaelen, MAUSKOPF, PHILIP, Moncelsi, Lorenzo, Netterfield, Calvin B., PASCALE, ENZO, Patanchon, Guillaume, Raymond, Gwenifer, Rex, Marie, Scott, Douglas, Semisch, Christopher, Siana, Brian, Truch, Matthew D. P., Viero, Marco P.   +18 more
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Temporal Pattern of Changes in Serum Biomarker Levels Reveal Complex and Dynamically Changing Pathologies after Exposure to a Single Low-intensity Blast in Mice

Frontiers in Neurology, 2015
Time dependent changes of protein biomarkers in the serum can help identifying the pathological processes and assessing the severity and progression of the disease in blast induced traumatic brain injury (bTBI). We obtained blood from naïve mice and mice
Farid eAhmed, Ibolja eCernak, Stefan ePlantman, Denes V Agoston, Denes V Agoston   +4 more
doaj   +1 more source

Blast Injury [PDF]

Military Medicine, 2011
Explosions can cause devastating injuries by various wounding mechanisms. Injuries due to the primary pressure wave are rarely life threatening and those that are lethal are uncommon. We reviewed the pathophysiology of blast-related injuries and their implications for management.
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Blast Loading of Small-Scale Circular RC Columns Using an Explosive-Driven Shock Tube

Buildings
Reinforced concrete (RC) columns, being axial-bearing components in buildings, are susceptible to damage and failure when subjected to blast loading. The failure of these columns can trigger a progressive collapse in targeted buildings.
Mohamed Ben Rhouma, Azer Maazoun, Aldjabar Aminou, Bachir Belkassem, Ignaas Vandenbruwane, Tine Tysmans, David Lecompte   +6 more
doaj   +1 more source

Characteristics and Impact of U.S. Military Blast-Related Mild Traumatic Brain Injury: A Systematic Review

Frontiers in Neurology, 2020
As a result of armed conflict, head trauma from exposure to blasts is an increasing critical health issue, particularly among military service members. Whilst numerous studies examined the burden of blast-related brain injuries on service members', few ...
Helen Phipps, Stefania Mondello, Stefania Mondello, Arlington Wilson, Travis Dittmer, Natalie N. Rohde, Paul J. Schroeder, Jaime Nichols, Camille McGirt, Justin Hoffman, Kaila Tanksley, Mariam Chohan, Amanda Heiderman, Hussein Abou Abbass, Firas Kobeissy, Sidney Hinds   +15 more
doaj   +1 more source