Results 71 to 80 of about 580,757 (317)

BLAST: THE REDSHIFT SURVEY [PDF]

The Astrophysical Journal, 2009
Accepted for publication in the Astrophysical Journal. Maps and associated results are available at http://blastexperiment.info/
Eales, Stephen, Chapin, Edward L., Devlin, Mark J., Dye, Simon, Halpern, Mark, Hughes, David H., Marsden, Gaelen, MAUSKOPF, PHILIP, Moncelsi, Lorenzo, Netterfield, Calvin B., PASCALE, ENZO, Patanchon, Guillaume, Raymond, Gwenifer, Rex, Marie, Scott, Douglas, Semisch, Christopher, Siana, Brian, Truch, Matthew D. P., Viero, Marco P.   +18 more
openaire   +4 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

BLAST: a more efficient report with usability improvements

Nucleic Acids Res., 2013
The Basic Local Alignment Search Tool (BLAST) website at the National Center for Biotechnology (NCBI) is an important resource for searching and aligning sequences. A new BLAST report allows faster loading of alignments, adds navigation aids, allows easy
G. Boratyn, Christiam Camacho, Peter S. Cooper, G. Coulouris, Amelia Fong, Ning Ma, Thomas L. Madden, Wayne Matten, S. D. McGinnis, Yuri Merezhuk, Yan Raytselis, E. Sayers, Tao Tao, Jian Ye, I. Zaretskaya   +14 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Characteristics and Impact of U.S. Military Blast-Related Mild Traumatic Brain Injury: A Systematic Review

Frontiers in Neurology, 2020
As a result of armed conflict, head trauma from exposure to blasts is an increasing critical health issue, particularly among military service members. Whilst numerous studies examined the burden of blast-related brain injuries on service members', few ...
Helen W Phipps, S. Mondello, A. Wilson, Travis A. Dittmer, Natalie N. Rohde, Paul J. Schroeder, J. Nichols, Camille McGirt, J. Hoffman, Kaila Tanksley, M. Chohan, A. Heiderman, Hussein Abou Abbass, F. Kobeissy, Sidney R. Hinds   +14 more
semanticscholar   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Blast Injury [PDF]

Military Medicine, 2011
Explosions can cause devastating injuries by various wounding mechanisms. Injuries due to the primary pressure wave are rarely life threatening and those that are lethal are uncommon. We reviewed the pathophysiology of blast-related injuries and their implications for management.
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Effective Assessment of Blast-Induced Ground Vibration Using an Optimized Random Forest Model Based on a Harris Hawks Optimization Algorithm

Applied Sciences, 2020
Most mines choose the drilling and blasting method which has the characteristics of being a cheap and efficient method to fragment rock mass, but blast-induced ground vibration damages the surrounding rock mass and structure and is a drawback. To predict,
Zhi Yu, Xiuzhi Shi, Jian Zhou, Xin Chen, Xianyang Qiu   +4 more
semanticscholar   +1 more source