Results 81 to 90 of about 864,284 (298)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Low Complexity V-BLAST MIMO-OFDM Detector by Successive Iterations Reduction

, 2015
V-BLAST detection method suffers large computational complexity due to its successive detection of symbols. In this paper, we propose a modified V-BLAST algorithm to decrease the computational complexity by reducing the number of detection iterations ...
Abuelenin, Sherif, Ahmed, Karam, Al-Barbary, Khairy, Soliman, Heba   +3 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Relativistic Jet Dynamics and Calorimetry of Gamma-Ray Bursts

, 2011
We present numerical solutions of the 2D relativistic hydrodynamics equations describing the deceleration and expansion of highly relativistic conical jets, of opening angles 0.05R/c observations.Comment: 5 pages, 5 ...
Berger, Cannizzo, Cenko, Frail, Granot, Granot, Klein, Livio, Panaitescu, Rhoads, Shivvers, Waxman, Waxman, Yost, Zhang, Zhang   +15 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Blast Loading of Small-Scale Circular RC Columns Using an Explosive-Driven Shock Tube

Buildings
Reinforced concrete (RC) columns, being axial-bearing components in buildings, are susceptible to damage and failure when subjected to blast loading. The failure of these columns can trigger a progressive collapse in targeted buildings.
Mohamed Ben Rhouma, Azer Maazoun, Aldjabar Aminou, Bachir Belkassem, Ignaas Vandenbruwane, Tine Tysmans, David Lecompte   +6 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

INTEGRATIVE MORPHO-MOLECULAR ANALYSIS OF Papilio polytes, Papilio polymnestor, AND Euploea core FROM JHARKHAND (INDIA) USING ADVANCED BIOTECHNOLOGICAL AND BIOINFORMATIC APPROACHES [PDF]

Biotechnologia Acta
Plants and butterflies have a coevolutionary relationship, and butterflies are essential to the ecosystem. They serve as ecosystem indicators as well since research on their populations and behaviour can reveal how healthy an environment is.
Kumar Manoj, Ranjan Rakesh, Pratik Raj , Tirkey Suraj , Kumar Aman, Hembrom Twinkle , Prasad S. Manoranjan, Singh R. Bharti   +7 more
doaj   +1 more source