Results 81 to 90 of about 580,757 (317)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Blast Loading of Small-Scale Circular RC Columns Using an Explosive-Driven Shock Tube

Buildings
Reinforced concrete (RC) columns, being axial-bearing components in buildings, are susceptible to damage and failure when subjected to blast loading. The failure of these columns can trigger a progressive collapse in targeted buildings.
Mohamed Ben Rhouma, Azer Maazoun, Aldjabar Aminou, Bachir Belkassem, Ignaas Vandenbruwane, Tine Tysmans, David Lecompte   +6 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Strategy for Use of Rice Blast Resistance Genes in Rice Molecular Breeding

, 2020
Rice blast is one of the most destructive diseases affecting rice production worldwide. The development and rational use of resistant varieties has been the most effective and economical measure to control blast. In this review, we summarized the cloning
Xiaoyan Ning, Wu Yunyu, Aihong Li
semanticscholar   +1 more source

INTEGRATIVE MORPHO-MOLECULAR ANALYSIS OF Papilio polytes, Papilio polymnestor, AND Euploea core FROM JHARKHAND (INDIA) USING ADVANCED BIOTECHNOLOGICAL AND BIOINFORMATIC APPROACHES [PDF]

Biotechnologia Acta
Plants and butterflies have a coevolutionary relationship, and butterflies are essential to the ecosystem. They serve as ecosystem indicators as well since research on their populations and behaviour can reveal how healthy an environment is.
Kumar Manoj, Ranjan Rakesh, Pratik Raj , Tirkey Suraj , Kumar Aman, Hembrom Twinkle , Prasad S. Manoranjan, Singh R. Bharti   +7 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Nonlinear dynamic behavior of simply-supported RC beams subjected to combined impact-blast loading

Engineering structures, 2019
Despite many studies existed in the literature on the investigation of reinforced concrete (RC) structures under impact or blast loads separately, this paper numerically evaluates the nonlinear dynamic responses and failure behaviors of simply-supported ...
Chunwei Zhang, Gholamreza Gholipour, A. Mousavi   +2 more
semanticscholar   +1 more source

Application of CRISPR/Cas9 Genome Editing Technology for the Improvement of Crops Cultivated in Tropical Climates: Recent Progress, Prospects, and Challenges

Frontiers in Plant Science, 2018
The world population is expected to increase from 7.3 to 9.7 billion by 2050. Pest outbreak and increased abiotic stresses due to climate change pose a high risk to tropical crop production.
Effi Haque, Hiroaki Taniguchi, Md. Mahmudul Hassan, Md. Mahmudul Hassan, Pankaj Bhowmik, M. Rezaul Karim, Magdalena Śmiech, Kaijun Zhao, Mahfuzur Rahman, Tofazzal Islam, Tofazzal Islam   +10 more
doaj   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source