Results 41 to 50 of about 142,290 (293)

A synoptic literature review of animal models for investigating the biomechanics of knee osteoarthritis

Frontiers in Bioengineering and Biotechnology
Osteoarthritis (OA) is a common chronic disease largely driven by mechanical factors, causing significant health and economic burdens worldwide. Early detection is challenging, making animal models a key tool for studying its onset and mechanically ...
Luyang Xu, Luyang Xu, Zepur Kazezian, Zepur Kazezian, Andrew A. Pitsillides, Anthony M. J. Bull, Anthony M. J. Bull   +6 more
doaj   +1 more source

Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation

Acta Neuropathologica Communications, 2021
Cerebral vascular injury as a consequence of blast-induced traumatic brain injury is primarily the result of blast wave-induced mechanical disruptions within the neurovascular unit.
Miguel A. Gama Sosa, Rita De Gasperi, Dylan Pryor, Georgina S. Perez Garcia, Gissel M. Perez, Rania Abutarboush, Usmah Kawoos, Seth Hogg, Benjamin Ache, William G. Janssen, Allison Sowa, Timothy Tetreault, David G. Cook, Susan J. Tappan, Sam Gandy, Patrick R. Hof, Stephen T. Ahlers, Gregory A. Elder   +17 more
doaj   +1 more source

The Libyan civil conflict : selected case series of orthopaedic trauma managed in Malta in 2014 [PDF]

, 2015
Aim: The purpose of this series of cases was to analyse our management of orthopaedic trauma casualties in the Libyan civil war crisis in the European summer of 2014. We looked at both damage control orthopaedics and for case variety of war trauma at a
Borg, Joseph N., Mifsud, Max, Mizzi, Colin, Ng, Colin   +3 more
core   +1 more source

Bomb blast injuries: an exploration of patient characteristics and outcome using Pakistan National Emergency Departments Surveillance (Pak-NEDS) data. [PDF]

, 2015
BACKGROUND: Bomb blast injuries result in premature deaths and burdening of healthcare systems. The objective of this study was to explore the characteristics and outcome of patients presenting to the emergency departments in Pakistan with bomb blast ...
Afridi, Shiraz Qayoom, Allen, Kate, Hyder, Adnan A., Kerai, Salima, Khan, Irum Qamar, Khan, Nadeem Ullah, Khan, Uzma Rahim, Naeem, Rubaba, Razzak, Junaid Abdul, Shahbaz, Sana, Siddiqui, Emaduddin, Zia, Nukhba   +11 more
core   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Behavioral Outcomes Differ Between Rotational Acceleration and Blast Mechanisms of Mild Traumatic Brain Injury

Frontiers in Neurology, 2016
Mild traumatic brain injury (mTBI) can result from a number of mechanisms, including blunt impact, head rotational acceleration, exposure to blast, and penetration of projectiles.
Brian D. Stemper, Brian D. Stemper, Alok S. Shah, Matthew D Budde, Matthew D Budde, Christopher eOlsen, Christopher eOlsen, Aleksandra eGlavaski-Joksimovic, Shekar N Kurpad, Michael eMcCrea, Frank A. Pintar, Frank A. Pintar   +11 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Blast-Associated Shock Waves Result in Increased Brain Vascular Leakage and Elevated ROS Levels in a Rat Model of Traumatic Brain Injury. [PDF]

PLoS ONE, 2015
Blast-associated shock wave-induced traumatic brain injury (bTBI) remains a persistent risk for armed forces worldwide, yet its detailed pathophysiology remains to be fully investigated.
Shushi Kabu, Hayder Jaffer, Marianne Petro, Dave Dudzinski, Desiree Stewart, Amy Courtney, Michael Courtney, Vinod Labhasetwar   +7 more
doaj   +1 more source

Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation [PDF]

, 2017
This study focuses on microstructural changes that occur within the mammalian lung when subject to blast and how these changes influence strain distributions within the tissue. Shock tube experiments were performed to generate the blast injured specimens
Andrikakou, Atwood, Barnett-Vanes, Basham, Bay, Black, Bodey, CR Bass, Denny, Eftaxiopoulou, Garner, Gillard, Hoppin, Kohsuke, Matsuda, Mercer, Nguyen, Palanca, Roberts, Schreier, Scott, Scott, Sera, Suki, Titarenko, Yuan   +25 more
core   +2 more sources