Results 31 to 40 of about 249,833 (291)

Energy Generation and Attenuation of Blast-Induced Seismic Waves under In Situ Stress Conditions

Applied Sciences, 2022
During blasting in deep mining and excavation, the rock masses usually suffer from high in situ stress. The initial seismic energy generated in deep rock blasting and its attenuation with distance is first theoretically analyzed in this study.
Jianhua Yang, Jinshan Sun, Yongsheng Jia, Yingkang Yao   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Research progress on permeability improvement mechanisms and technologies of coalbed deep-hole cumulative blasting

International Journal of Coal Science & Technology, 2020
Coalbed gas extraction is an important means of exploiting and utilizing gas resources, as well as a means of preventing coal mine disasters. In view of the low gas extraction rate from coalbeds with high gas content and low permeability, a method of ...
D. Guo, P. Lv, Jiechao Zhao, Chao Zhang
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Advances in Novel Structures and Materials for Shaped Charge Liners

Shock and Vibration
As a core component of shaped charges, the liner’s structural and material properties are crucial for overcoming traditional technological limitations and enhancing the cumulative effect in applications involving civil explosives and resource extraction.
Yihao Shen, Zhichao Zhao, Zhangbo Ming, Guangyu Yin, Yurong Liu, Jingwei Li, Xuwen Liu   +6 more
doaj   +1 more source

Ultra-high pulse pressure induced particle surface thermal field assisted preparation of W–Al composite

Journal of Materials Research and Technology
Particle surface thermal field (PSTF) is an inhomogeneous thermal field that concentrates the heat effect on the surface of particles, and it can be utilized to fabricate composite materials with large differences in physical properties.
Jianian Hu, Haotian Zhang, Xiang Chen, Jian Zhang   +3 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Numerical investigation into the blasting-induced damage characteristics of rocks considering the role of in-situ stresses and discontinuity persistence

Computers and geotechnics, 2019
This paper presents a 3D coupled Smoothed Particle Hydrodynamics (SPH) and Finite Element Method (FEM) model, which was developed to investigate the extent of damage zone and fracture patterns in rock due to blasting.
L. B. Jayasinghe, J. Shang, Zhiye Zhao, A. Goh   +3 more
semanticscholar   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source