Results 111 to 120 of about 147,588 (334)
Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. [PDF]
, 1989 Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties ...
Cui, TY +7 more
core +3 more sources
New biosensors and transgenic mice for multiplex cGMP imaging
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters +6 more
wiley +1 more source
Revista Colombiana de Ciencias Pecuarias, 2010 The purpose of this study was to determine the in vitro expansion and hatching rates of vitrified mouse blastocysts loaded into glass micro-capillaries (Brand® - 5 μL).
Paula Rodríguez V +4 more
doaj
IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope
Cancer Science, EarlyView.This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio +20 more
wiley +1 more source
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, EarlyView.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
Cell Proliferation, EarlyView.Transcriptional and translational characteristics during goat oocyte maturation and identification of key factors, including GTPBP4, for prepubertal goat oocyte maturation. ABSTRACT The intricate mechanisms driving oocyte maturation remain only partially understood, especially within the domains of domestic animal reproduction and translational ...
Jianpeng Qin +21 more
wiley +1 more source
Bta-miR-10b secreted by bovine embryos negatively impacts preimplantation embryo quality [PDF]
, 2019 In a previous study, we found miR-10b to be more abundant in a conditioned culture medium of degenerate embryos compared to that of blastocysts. Here, we show that miR-10b mimics added to the culture medium can be taken up by embryos. This uptake results
Deforce, Dieter +6 more
core +1 more source
Bioessays, 2015 The mammalian blastocyst exhibits a high capacity for aerobic glycolysis, a metabolic characteristic of tumours. It has been considered that aerobic glycolysis is a means to ensure a high carbon flux to fulfil biosynthetic demands.
D. Gardner
semanticscholar +1 more source
Autophagy in PE: Dispute, Role and Potential Target
Cell Proliferation, EarlyView.Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu +12 more
wiley +1 more source