Results 111 to 120 of about 110,172 (282)

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

EXTRACELLULAR VESICLE PROFILING OF SPENT HUMAN BLASTOCYST MEDIA BY NANOSCALE FLOW CYTOMETRY [PDF]

, 2023
Thomas O’Leary, Mayu Morita, Elizabeth S. Rubin, Jacqueline Budrewicz, Shawn L. Chavez   +4 more
openalex   +1 more source

Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci

Cell Proliferation, EarlyView.
To identify novel imprinted genes, parthenogenetic, androgenetic and biparental human embryonic stem cells and their differentiated neural progenitors were analysed by methylome and transcriptome profiling. This approach uncovered 12 putative novel imprinted genes, including a clustered region on chromosome 19, expanding the current catalogue of ...
Shay Kinreich, Nissim Benvenisty
wiley   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Challenges and possible clinical applications of human embryonic stem cell research [PDF]

, 2012
Human embryonic stem cells (hESC) are harvested from the inner cell mass of the pre-implantation embryo and possess several unique characteristics. First, they are self-renewing, meaning they can grow indefinitely in an appropriate culture environment ...
De Sutter, Petra, Heindryckx, Björn, O'Leary, Thomas, Van der Jeught, Margot   +3 more
core   +1 more source

Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss

Equine Veterinary Journal, EarlyView.
Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez, Alejandro de la Fuente, Kazuki Takahashi, Hugo Monteiro, Mauricio Mendes, Stuart Meyers, Pouya Dini   +6 more
wiley   +1 more source

Shedding light on the parasite communities and diet of the deep‐sea shark Deania profundorum (Smith & Radcliffe, 1912) (Squaliform: Centrophoridae) from the Avilés Canyon (southern Bay of Biscay)

Journal of Fish Biology, EarlyView.
Abstract Deep‐sea elasmobranchs are less resilient to the increasing scale of anthropogenic impacts such as fisheries, owing to their life‐history traits. The necessity for proper management measures is hampered by the scant knowledge on these taxa and their biology. Here we provide the first comprehensive insight into the parasite infracommunities and
Wolf Isbert, Cristina Rodríguez‐Cabello, Francisco E. Montero, Maite Carrassón, Inmaculada Frutos, Ana Pérez‐del‐Olmo   +5 more
wiley   +1 more source

Blastocysts originated from oocytes with smooth endoplasmic reticulum aggregates have a reduced euploidy rate: a retrospective cohort study

Frontiers in Endocrinology
Research questionDoes the presence of smooth endoplasmic reticulum aggregates (SERa) in oocytes adversely impact the euploidy rate of subsequent blastocysts?DesignWe performed a retrospective cohort study with 671 young patients (< 38 years ...
Pengcheng Kong, Jiaping Pan, Shanshan Liang, Mingru Yin, Xiaoming Teng   +4 more
doaj   +1 more source

Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation

, 2023
Marina Segura-Benítez, Alba Bas-Rivas, Elena Juárez‐Barber, María Cristina Carbajo‐García, Amparo Faus, María José de los Santos, António Pellicer, Hortensia Ferrero   +7 more
openalex   +2 more sources

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source