ABSTRACT Objectives To determine the prognostic value of serum β‐human chorionic gonadotropin (β‐hCG) for predicting live birth following single euploid frozen‐embryo transfer (FET), and to develop and validate a prognostic model (iHOPE) for this purpose. Methods This retrospective cohort study used data from two large fertility practices.
E. Kalafat +8 more
wiley +1 more source
Impact of lauric acid supplementation on bovine oocyte maturation, IVF embryo development, and stress protection during IVM. [PDF]
Truong ND +5 more
europepmc +1 more source
Liminal Bioethics for Liminal Statuses: A New Method for Analysing Novel Biological Entities
ABSTRACT Novel biological entities such as cell lines and organoids do not typically fit into established conceptual categories, such as ‘human’ or ‘nonhuman’, ‘gift’ or ‘property’. This makes developing robust ethical principles or policy solutions difficult.
Michael Wee, Ilina Singh
wiley +1 more source
ICSI shows no advantage over conventional IVF in patients with unexpected low oocyte yield. [PDF]
Li M, Chen W, Xue X, Shi J.
europepmc +1 more source
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong +9 more
wiley +1 more source
Development and validation of a predictive model for early blastocyst formation on day 4 post-fertilization. [PDF]
Geng Y +6 more
europepmc +1 more source
Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci
To identify novel imprinted genes, parthenogenetic, androgenetic and biparental human embryonic stem cells and their differentiated neural progenitors were analysed by methylome and transcriptome profiling. This approach uncovered 12 putative novel imprinted genes, including a clustered region on chromosome 19, expanding the current catalogue of ...
Shay Kinreich, Nissim Benvenisty
wiley +1 more source
MUC1 Protects Preimplantation Embryos In Vitro via Clearance of ROS by Triggering Mitophagy. [PDF]
Yang J +9 more
europepmc +1 more source
Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang +10 more
wiley +1 more source
Developmental Morphokinetics and the Transcriptomic Profile of Bovine First-Cleaved Embryos: Normal vs. Abnormal Divisions. [PDF]
Michaelov A, Kalo D, Gershoni M, Roth Z.
europepmc +1 more source

