Results 131 to 140 of about 147,588 (334)

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

open access: yesThe FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický   +22 more
wiley   +1 more source

Tracing blastomere fate choices of early embryos in single cell culture [PDF]

open access: yes, 2010
Blastomeres of early vertebrate embryos undergo numerous fate choices for division, motility, pluripotency maintenance and restriction culminating in various cell lineages.
Chang Ming Li   +11 more
core   +1 more source

Intrauterine administration of human chorionic gonadotropin does not improve pregnancy and life birth rates independently of blastocyst quality: a randomised prospective study

open access: yesReproductive Biology and Endocrinology, 2015
BackgroundSuccessful embryo implantation depends on a well-timed maternal-embryonic crosstalk. Human chorionic gonadotropin (hCG) secreted by the embryo is known to play a key role in this process and to trigger a complex signal transduction cascade ...
B. Wirleitner   +9 more
semanticscholar   +1 more source

Current Progress of Tissue Engineering With Stem Cells in Urology Updated Review in 2025

open access: yesInternational Journal of Urology, EarlyView.
ABSTRACT Tissue engineering, a key component of regenerative medicine, aims to restore the structure and function of damaged organs using combinations of cells, scaffolds, and bioactive factors. In urology, the integration of stem cell biology has fueled significant progress in preclinical models for kidney, bladder, and urethral regeneration ...
Kenichi Kobayashi   +5 more
wiley   +1 more source

Understanding the ethical concerns that have shaped European regulation of human embryonic stem cell research [PDF]

open access: yes, 2012
Human embryonic stem cell research has generated much hope, but also fear and repulsion. National legislators, as well as the European Parliament, the European Patent Office and the European Court of Justice have had to make decisions relating to what is
Mertes, Heidi
core  

Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications

open access: yesObesity Reviews, EarlyView.
ABSTRACT Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenesis that includes disordered follicle development, hypothalamic–pituitary–ovarian (HPO) axis dysfunction, hyperandrogenemia, and insulin resistance. The risk of complications during pregnancy, such as gestational diabetes mellitus (GDM) and preeclampsia (PE)
Shaohua Zhang   +5 more
wiley   +1 more source

Recryopreservation impairs blastocyst implantation potential via activated endoplasmic reticulum stress pathway and induced apoptosis

open access: yesMedComm
Recryopreservation (recryo) is occasionally applied in clinical, while the underlying mechanism of impaired clinical outcomes after recryo remains unclear.
Meng Wang   +9 more
doaj   +1 more source

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