Results 131 to 140 of about 138,167 (340)

Intrauterine administration of human chorionic gonadotropin does not improve pregnancy and life birth rates independently of blastocyst quality: a randomised prospective study

open access: yesReproductive Biology and Endocrinology, 2015
BackgroundSuccessful embryo implantation depends on a well-timed maternal-embryonic crosstalk. Human chorionic gonadotropin (hCG) secreted by the embryo is known to play a key role in this process and to trigger a complex signal transduction cascade ...
B. Wirleitner   +9 more
semanticscholar   +1 more source

Understanding the ethical concerns that have shaped European regulation of human embryonic stem cell research [PDF]

open access: yes, 2012
Human embryonic stem cell research has generated much hope, but also fear and repulsion. National legislators, as well as the European Parliament, the European Patent Office and the European Court of Justice have had to make decisions relating to what is
Mertes, Heidi
core  

Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling

open access: yesCell Proliferation, EarlyView.
Paracrine FGF4 from EPI precursor cells promotes lactate synthesis within PrE precursor cells, while the increased lactate in turn stimulates FGF‐ERK signalling via lactate shuttling. The increased lactate in PrE precursor cells directly promotes PrE formation by elevating the level of histone lactylation. ABSTRACT Lactate has been widely recognised as
Xiao Hu   +9 more
wiley   +1 more source

Slow freezing cryopreservation of Korean bovine blastocysts with an additional sucrose pre-equilibration step

open access: yesFrontiers in Veterinary Science
IntroductionEmbryo cryopreservation is a valuable technique used for preserving genetic resources for long periods. However, the survival rate of embryos is dependent on the method used.
Seungki Jung   +9 more
doaj   +1 more source

Autophagy in PE: Dispute, Role and Potential Target

open access: yesCell Proliferation, EarlyView.
Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu   +12 more
wiley   +1 more source

Blastocysts originated from oocytes with smooth endoplasmic reticulum aggregates have a reduced euploidy rate: a retrospective cohort study

open access: yesFrontiers in Endocrinology
Research questionDoes the presence of smooth endoplasmic reticulum aggregates (SERa) in oocytes adversely impact the euploidy rate of subsequent blastocysts?DesignWe performed a retrospective cohort study with 671 young patients (< 38 years ...
Pengcheng Kong   +4 more
doaj   +1 more source

Transcription Factor TCF12‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation

open access: yesCell Proliferation, EarlyView.
Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao   +7 more
wiley   +1 more source

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