Results 61 to 70 of about 149,494 (327)

Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies

Frontiers in Cell and Developmental Biology, 2019
To become fertile, mammalian sperm must undergo a series of biochemical and physiological changes known as capacitation. These changes involve crosstalk between metabolic and signaling pathways and can be recapitulated in vitro.
Felipe A. Navarrete, Luis Aguila, David Martin-Hidalgo, David Martin-Hidalgo, Darya A. Tourzani, Guillermina M. Luque, Goli Ardestani, Francisco A. Garcia-Vazquez, Francisco A. Garcia-Vazquez, Lonny R. Levin, Jochen Buck, Alberto Darszon, Mariano G. Buffone, Jesse Mager, Rafael A. Fissore, Ana M. Salicioni, María G. Gervasi, Pablo E. Visconti   +17 more
doaj   +1 more source

Mechanics of mouse blastocyst hatching revealed by a hydrogel-based microdeformation assay

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Blastocyst hatching is crucial for implantation of mammalian embryos and a common failure point during in vitro fertilization (IVF). We have little knowledge of the mechanical basis whereby an embryo hatches out of the zona pellucida.
K. Leonavicius, C. Royer, Chris Preece, B. Davies, J. Biggins, S. Srinivas   +5 more
semanticscholar   +1 more source

Genetic Normalization of Differentiating Aneuploid Human Embryos [PDF]

, 2011
Early embryogenesis involves a series of dynamic processes, many of which are currently not well described or understood. Aneuploidy and aneuploid mosaicism, a mixture of aneuploid and euploid cells within one embryo, in early embryonic development are ...
Andrew Barker, Andrew Benner, Garry Cutting, Kevin Richter, Khanh-Ha Nguyen, Paul Brezina, Raymond Anchan, Ric Ross, William Kearns   +8 more
core   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

Future Perspectives of POSEIDON Stratification for Clinical Practice and Research

Frontiers in Endocrinology, 2019
A total of 50% of patients undergoing IVF treatment has previously been estimated to fulfill the POSEIDON classification criteria; importantly, although the reproductive prognosis differs between patients, POSEIDON patients share the same characteristic ...
Peter Humaidan, Peter Humaidan, Antonio La Marca, Carlo Alviggi, Carlo Alviggi, Sandro C. Esteves, Sandro C. Esteves, Sandro C. Esteves, Sandro C. Esteves, Thor Haahr, Thor Haahr   +10 more
doaj   +1 more source

Prostaglandins in Swine Blastocysts [PDF]

Biology of Reproduction, 1983
The activity of phospholipase A2 (PLA2) and the content of prostaglandins (PGF and PGE-A) in swine blastocysts were determined on Days 7 through 14 of gestation by using radioenzymatic and radioimmunoassay techniques. Both PLA2 activity and PG content increased in the blastocyst with age.
D L, Davis, P L, Pakrasi, S K, Dey
openaire   +2 more sources

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

Mechanisms of Development, 2015
Here, we provide fundamental insights into early human development by single-cell RNA-sequencing of human and mouse preimplantation embryos. We elucidate conserved transcriptional programs along with those that are human specific.
Paul Blakeley, N. Fogarty, I. del Valle, Sissy E. Wamaitha, T. X. Hu, K. Elder, Phil Snell, Leila Christie, P. Robson, Kathy K. Niakan   +9 more
semanticscholar   +1 more source

NaNog: A pluripotency homeobox (master) molecule. [PDF]

, 2015
One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed necessary , then at a specified time can differentiate into any type of cell. This fundamental process
Aguib, YE, Allouba, MH, ElGuindy, AM, Krishnamoorthy, N, Yacoub, MH   +4 more
core   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source