Results 41 to 50 of about 20,947 (214)

Computer vision for automatic identification of blastocyst structures and blastocyst formation time in In-Vitro Fertilization [PDF]

Embryo selection is an indispensable step to ensure the success of In-Vitro Fertilization; however, this decision is a time-consuming, laborious, and highly subjective task for embryologists.
Malo, Clara, Ayensa-Jiménez, Jacobo [0000-0003-2564-6038], Urries, Antonio, Villota, María, Ayensa-Jiménez, Jacobo, Heras, Jónathan, Doblaré, Manuel, Doblaré, Manuel [0000-0001-8741-6452], Heras, Jónathan [0000-0003-4775-1306]   +8 more
core   +1 more source

Robotic Manipulation of Embryos for Blastocyst Evaluation [PDF]

, 2022
Infertility is a global public health issue, affecting 15% of couples worldwide. In in vitro fertilization (IVF) treatment, blastocyst evaluation is routinely conducted to select Day 5/6 embryos (so-called blastocysts) that are free of chromosomal ...
Shan, Guanqiao
core   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

Can Blastocyst Morphometrics Be a Non-invasive Predictive Marker for Clinical Pregnancy in In vitro Fertilisation Cycles? A Prospective Cohort Study

Journal of Human Reproductive Sciences
Background: Blastocyst diameter is a key morphometric indicator used to predict implantation. Some studies suggest, well-expanded blastocysts generally demonstrate significantly higher clinical pregnancy and live birth rates compared to smaller embryos ...
Neeta Singh, Supriya Kumari, Monika Saini, Maroof Ahmad Khan   +3 more
doaj   +1 more source

Synchrony of the first division as an index of the blastocyst formation rate during embryonic development

Reproductive Medicine and Biology, 2018
Purpose To devise an uninvasive selection system for human embryos with high developmental potential after a single oocyte retrieval cycle by comparing the in vitro and in vivo effectiveness of first division synchrony against subsequent embryonic ...
Yamato Mizobe, Makoto Tokunaga, Naoto Oya, Reiko Iwakiri, Naomi Yoshida, Yumi Sato, Nanase Onoue, Yuji Ezono   +7 more
doaj   +1 more source

Genetic Normalization of Differentiating Aneuploid Human Embryos [PDF]

, 2011
Early embryogenesis involves a series of dynamic processes, many of which are currently not well described or understood. Aneuploidy and aneuploid mosaicism, a mixture of aneuploid and euploid cells within one embryo, in early embryonic development are ...
Paul Brezina, Raymond Anchan, Kevin Richter, Ric Ross, Andrew Benner, William Kearns, Andrew Barker, Khanh-Ha Nguyen, Garry Cutting   +8 more
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Efficient derivation of embryonic stem cells and primordial germ cell-like cells in cattle

The Journal of Reproduction and Development
The induction of the germ cell lineage from pluripotent stem cells (in vitro gametogenesis) will help understand the mechanisms underlying germ cell differentiation and provide an alternative source of gametes for reproduction.
Atsushi SHIRASAWA, Masafumi HAYASHI, Mayumi SHONO, Atsushi IDETA, Takashi YOSHINO, Katsuhiko HAYASHI   +5 more
doaj   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source