Results 21 to 30 of about 65,555 (189)

A novel isolator-based system promotes viability of human embryos during laboratory processing

, 2012
In vitro fertilisation (IVF) and related technologies are arguably the most challenging of all cell culture applications. The starting material is a single cell from which one aims to produce an embryo capable of establishing a pregnancy eventually ...
Fenwick, Jeanette, Watson Bruce, Mary Herbert, Samantha Byerley (180223), Watson, Bruce, Prathalingam Nilendran, Byerley Samantha, John Rhodes (180227), Nowak, Lynne, John Rhodes, Louise Hyslop, Henderson Robin, Byerley, Samantha, Steve Harbottle (180219), Harbottle, Steve, Harbottle Steve, Herbert, Mary, Henderson, Robin, Robin Henderson (180237), Steve Harbottle, Louise Hyslop (180204), Rhodes, John, Fenwick Jeanette, Lynne Nowak (180212), Bruce Watson (180231), Hyslop Louise, Jeanette Fenwick (180215), Samantha Byerley, Murdoch, Alison, Nilendran Prathalingam, Rhodes John, Robin Henderson, Lynne Nowak, Bruce Watson, Herbert Mary, Singh, Shree Ram, Alison Murdoch (180242), Murdoch Alison, Hyslop, Louise, Mary Herbert (180245), Prathalingam, Nilendran, Jeanette Fenwick, Nowak Lynne, Alison Murdoch, Nilendran Prathalingam (180208)   +44 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Bivariate analysis of basal serum anti-Müllerian hormone measurements and human blastocyst development after IVF [PDF]

, 2011
Background To report on relationships among baseline serum anti-Müllerian hormone (AMH) measurements, blastocyst development and other selected embryology parameters observed in non-donor oocyte IVF cycles.
Brady, A.C., Brady, Adam C., Kevin D Marron, Walsh, Anthony P.H., Peck, Alison C., Collins, Gary, Collins, G.S., Walsh, David J., Anthony PH Walsh, Salem, RD, Kevin D. Marron (7952234), Rifaat D. Salem (7952279), David J. Walsh (2643388), Adam C. Brady (7952219), Anthony PH Walsh (7952207), Marron, Kevin D., Brady Adam C, Salem, Rifaat D., Peck, A.C., Alison C Peck, E Scott Sills, Marron, K.D., Sills, ES, Collins Gary S, Peck Alison C, Gary S Collins, Marron Kevin D, Peck, AC, Walsh, D.J., Salem Rifaat D, Gary S. Collins (7952288), Walsh, DJ, Salem, R.D., Walsh David J, Brady, AC, Sills E Scott, Rifaat D Salem, David J Walsh, Collins, GS, Alison C. Peck (7952291), Collins, Gary S.; id_orcid, Walsh, A.P.H., Sills, E. Scott, Sills, E.S., Eric Scott Sills (6129536), Walsh Anthony PH, Adam C Brady, Walsh, AP, Marron, KD   +48 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Defragmentation of in-vitro fertilization blastocyst stage embryos leading to rescued blastocyst expansion and clinical pregnancy

, 2023
Embryo fragmentation, or extrusion of cell fragments, is a naturally occurring phenomenon that may be associated with impaired embryo development, failed implantation and decreased pregnancy rates.
Chae-Kim, Jennifer J., Waggener, K., Gavrilova-Jordan, L., NC DOCKS at East Carolina University   +3 more
core  

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Blastocyst formation rate.

, 2015
The blastocyst formation rate of the fertilized eggs collected from 5-week-old Kunming mice. The table presents the number of fertilized eggs collected from five mice. The values represent the rate of successful blastocyst development.* P>0.05 vs control-
Na Zhao (112953), Qun Liu (67203), Wenpei Xiang (740209), Yong Zhang (5893)   +3 more
core   +1 more source