Results 51 to 60 of about 20,947 (214)

Neurotrophin-4 promotes the specification of trophectoderm lineage after parthenogenetic activation and enhances porcine early embryonic development

Frontiers in Cell and Developmental Biology, 2023
Neurotrophin-4 (NT-4), a neurotrophic factor, appears to affect early embryonic development because it is secreted not only by neurons but also by oviductal and uterine epithelial cells. However, no studies have characterized the effects of NT-4 on early
Mirae Kim, Mirae Kim, Joohyeong Lee, Joohyeong Lee, Lian Cai, Lian Cai, Lian Cai, Hyerin Choi, Hyerin Choi, Dongjin Oh, Dongjin Oh, Ali Jawad, Ali Jawad, Sang-Hwan Hyun, Sang-Hwan Hyun, Sang-Hwan Hyun   +15 more
doaj   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Leukemia Inhibitory Factor Stimulates Primitive Endoderm Expansion in the Bovine Inner Cell Mass

Frontiers in Animal Science, 2021
Previous work determined that bovine interleukin-6 (IL6) increases inner cell mass (ICM), primitive endoderm (PE), and total cell number in in vitro produced (IVP) bovine blastocysts.
Lydia K. Wooldridge, Alan D. Ealy
doaj   +1 more source

Defragmentation of in-vitro fertilization blastocyst stage embryos leading to rescued blastocyst expansion and clinical pregnancy

, 2023
Embryo fragmentation, or extrusion of cell fragments, is a naturally occurring phenomenon that may be associated with impaired embryo development, failed implantation and decreased pregnancy rates.
Chae-Kim, Jennifer J., Waggener, K., Gavrilova-Jordan, L., NC DOCKS at East Carolina University   +3 more
core  

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Blastocyst formation rate.

, 2015
The blastocyst formation rate of the fertilized eggs collected from 5-week-old Kunming mice. The table presents the number of fertilized eggs collected from five mice. The values represent the rate of successful blastocyst development.* P>0.05 vs control-
Na Zhao (112953), Qun Liu (67203), Wenpei Xiang (740209), Yong Zhang (5893)   +3 more
core   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Association between early βhCG kinetics, blastocyst morphology and pregnancy outcome in a single-blastocyst transfer program

, 2018
International audienceObjective(s): Beta human chorionic gonadotrophin (b-hCG) is secreted by placenta and detectable in maternal serum a few days after embryo implantation.
Tiphaine Lefebvre, Simorre, Mathilde, Leperlier, Florence, Fréour, Thomas, Girard, Jean-Maxime, Mathilde Simorre, Barrière, Paul, Jean-Maxime Girard, Reignier, Arnaud, Thomas Fréour, Paul Barrière, Lefebvre, Tiphaine, Florence Leperlier, Arnaud Reignier   +13 more
core   +1 more source

Association between blastocyst morphology and maternal first trimester serum markers in ongoing pregnancies obtained after single fresh blastocyst transfer

, 2021
International audienceIs there an association between blastocyst morphology and maternal first trimester serum markers in In Vitro Fertilization (IVF) pregnancies obtained after fresh single blastocyst ...
Fréour, Thomas, Lefebvre, Tiphaine, Goronflot, Thomas, Barrière, Paul, Pérennec, Audrey, Masson, Damien, Gourraud, Pierre-Antoine, Reignier, Arnaud   +7 more
core   +1 more source