Results 191 to 200 of about 13,979 (215)

B lymphocyte/carcinoma antigen (BLCa): Functional study in B cells

Immunology and Cell Biology, 1988
SummaryBLCa is an antigen expressed on the surface of B lymphocytes and certain carcinomas. In this study we have demonstrated that BLCa is distinct from known B cell antigens classified by ‘clusters of differentiation’ (CD). In particular, the monoclonal antibody MA6, which identifies BLCa, can be distinguished from antibodies of the CDw40 group ...
P J Macardle, J Bradley
exaly   +3 more sources

Biodistributions of intact monoclonal antibodies and fragments of BLCA-38, a new prostate cancer directed antibody

Cancer Immunology, Immunotherapy, 2004
Monoclonal antibodies (MAbs) are used for targeting agents to tumours while minimizing normal tissue exposure.A new anti-prostate cancer MAb, BLCA-38, was radioiodinated (I125) and assessed for its ability to target subcutaneous human prostate cancer (DU-145) xenografts after systemic intraperitoneal administration.
Pamela Russell, Larissa Doughty, Alexander A Kortt   +2 more
exaly   +3 more sources

Association of BLCA-4 Hypomethylation in Blood Leukocyte DNA and the Risk of Bladder Cancer in a Chinese Population

Pathology and Oncology Research, 2012
Global DNA hypomethylation has been associated with increased risk for cancers of the colorectum, bladder, breast, head and neck, and testicular germ cells. The aim of this study was to examine whether global hypomethylation measured at BLCA-4 repeat regions through bisulfite pyrosequencing in blood leukocyte DNA is associated with the risk of bladder ...
Zhiwen Chen, Zhan-Song Zhou
exaly   +3 more sources

A SHARED ANTIGENIC DETERMINANT BETWEEN HUMAN B LYMPHOCYTES AND CARCINOMAS (BLCa)

International Journal of Cancer, 1985
We have raised a murine 1gM monoclonal antibody (MA6) against immunoprecipitate obtained by reacting the serum of an NPC patient with extract of the Burkitt lymphoma cell line, Raji. It reacts against an antigen (BLCa) which is broadly represented on human B lymphoid tissues and cell lines but is different from the functional B‐cell markers such as ...
K H, Chan, T C, Yip, W L, Ng, M H, Ng
openaire   +2 more sources

An Enhanced-BLCA for Assessing Performance of Company's Growth

2019 7th International Conference on Cyber and IT Service Management (CITSM), 2019
This paper purposes an improved algorithm of the butterfly lifecycle for calculating the performance of the company's growth. Three types of change for the better are regarding mathematical model, conception in calculating the growth performance parameters, and also data operated practically for testing the proposed algorithm.
openaire   +1 more source

Urinary BLCA-4 level is useful to detect upper urinary tract urothelial cell carcinoma

Actas Urológicas Españolas (English Edition), 2012
Upper urinary tract urothelial cell carcinomas (UUT-UCCs) are rare but usually invasive at diagnosis. Early diagnosis of UUT-UCCs is thus warranted. UUT has the same embryological origin with bladder and BLCA-4 is a highly sensitive and specific marker for bladder cancer.
C-C, Feng, Z, Wu, H-W, Jiang, H, Wen, M, Guan, Q, Ding   +5 more
exaly   +3 more sources

Preliminary findings on the development of a predictive model for BLCA based on disulfidptosis-associated IncRNAs signature

BMC Urology
Abstract Background Bladder urothelial carcinoma (BLCA) is the most common malignancy of the urinary tract, presenting with a wide range of clinical symptoms and prognosis. Disulfidptosis is a newly identified cell death method and closely associated with BLCA progression, prognosis, and ...
Chao Tang, Yanpeng Fan, Shusheng Zhu
exaly   +4 more sources

PDGFRA exhibits potential as an indicator of angiogenesis within the tumor microenvironment and is up-regulated in BLCA

Microvascular Research
Bladder cancer (BLCA) is a common type of urogenital malignancy worldwide. The recurrence and metastasis of bladder cancer are closely related to angiogenesis, but the underlying mechanisms are unclear. In this study, we developed a method to predict survival outcomes among BLCA patients, which could be used to guide immunotherapy and chemotherapy.
Yuyang, Hou, Wenjing, Du, Qiong, Wu, Xinyu, Chai, Yinan, Wang, Yingqian, Mi, Yuan, Tian, Mengyan, Tang, Jun, Li, Dongmei, Yan   +9 more
openaire   +2 more sources

BLCA-4 and UBC combined detection for early diagnosis of bladder cancer.

Journal of biological regulators and homeostatic agents, 2016
The objective of the present study was to report the clinical significance of bladder cancer specific nuclear matrix protein 4 (BLCA-4) and urinary bladder cancer (UBC) on early diagnosis of bladder cancers. Enzyme-linked immunosorbent assay (ELISA) was used to detect BLCA-4 and UBC of 56 bladder cancer patients and 26 patients with urinary tract ...
L, Cui, M M, Sun, Z H, Zhao, J P, Yang, Y P, Zheng, L L, He, K S, Chen, Q X, Fan   +7 more
openaire   +1 more source

Detection of bladder cancer using a novel nuclear matrix protein, BLCA-4.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2000
We have identified previously six nuclear matrix proteins (NMPs) that are bladder cancer specific. In this study, we analyzed the expression of one of these proteins, BLCA-4, in bladder tumors and normal bladder tissue. We also examined the appearance of BLCA-4 in the urine as a biomarker for bladder cancer.
B R, Konety, T S, Nguyen, R, Dhir, R S, Day, M J, Becich, W M, Stadler, R H, Getzenberg   +6 more
openaire   +1 more source